Evidence map›Paper›PMID 33919318›Full record

ArticleMicroorganisms2021

Tick-Borne Encephalitis Vaccination Protects from Alimentary TBE Infection: Results from an Alimentary Outbreak.

Lidia Chitimia-Dobler, Alexander Lindau, Rainer Oehme, Malena Bestehorn-Willmann, Markus Antwerpen, Marco Drehmann, Thomas Hierl, Ute Mackenstedt, Gerhard Dobler

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Langat Virus Biology and Infection.Reviews in medical virology · 2026
    Review
  3. Tick-Borne Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023
    Article
  4. [Viral zoonoses in Germany: a One Health perspective].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023
    Review
  5. Article
  6. Article
  7. Food-Borne Transmission of Tick-Borne Encephalitis Virus-Spread, Consequences, and Prophylaxis.International journal of environmental research and public health · 2022
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lidia Chitimia-DoblerBundeswehr Institute of Microbiology, 80937 Munich, Germany.
Alexander LindauDepartment of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany.
Rainer OehmeState Health Office Baden-Württemberg, 70191 Stuttgart, Germany.
Malena Bestehorn-WillmannDepartment of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany.
Markus AntwerpenBundeswehr Institute of Microbiology, 80937 Munich, Germany.
Marco DrehmannDepartment of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany.
Thomas HierlDistrict Health Office Zollernalbkreis, 72379 Hechingen, Germany.
Ute MackenstedtDepartment of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany.
Gerhard DoblerBundeswehr Institute of Microbiology, 80937 Munich, Germany.
University of Hohenheim · DEUniversität der Bundeswehr München · DEInstitut für Mikrobiologie der Bundeswehr

Funding

Zoonoses Sequencing Network BMBF-ZooSeq 01KI2010A, 01KI2010C, 01KI1905A
6 · The paper itself

Abstract

In May 2017, a hospitalized index case of tick-borne encephalitis (TBE) was confirmed by Serology. The case was linked to alimentary infection by raw milk from a goat farm in the region of Tübingen, Baden-Württemberg, Germany, where no previous TBE cases in the area had been reported before. The TBE focus was confirmed by isolation of the TBE virus from ticks and Serological confirmation of past infection in one of the five flock goats. Additional investigations by the local public health office identified 27 consumers of goat milk at the putative period of exposure. For 20/27 exposed persons, anamnestic information was gained by the local public health office. Twelve/fourteen exposed and non-vaccinated people developed clinical illness and were confirmed as TBE cases by Serology. Five/six vaccinated and exposed people did not develop the disease. The one exposed and vaccinated person had their last TBE vaccination booster more than 15 years ago, and therefore a booster was more than 10 years overdue. None of the regularly vaccinated and exposed persons developed clinical overt TBE infection. We report the first known TBE outbreak, during which, protection by TBE vaccination against alimentary TBE infection was demonstrated.

Indexed as

alimentary infectiongoat milktick-borne encephalitis virus

Identifiers

PMID33919318
PMCPMC8143337
OpenAlexW3154891387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.