Evidence map›Paper›PMID 33919281›Full record

ArticleGenes2021

Clinicopathologic Profile of Breast Cancer in Germline ATM and CHEK2 Mutation Carriers.

Angela Toss, Elena Tenedini, Claudia Piombino, Marta Venturelli, Isabella Marchi, Elisa Gasparini, Elena Barbieri, Elisabetta Razzaboni, Federica Domati, Federica Caggia and 6 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. International journal of molecular sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. ATM c.7570G>C is a high-risk allele for breast cancer.International journal of cancer · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Angela TossDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.ORCID 0000-0002-1854-6701
Elena TenediniDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0003-0285-765X
Claudia PiombinoDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.ORCID 0000-0002-7224-4536
Marta VenturelliDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.ORCID 0000-0003-0658-8004
Isabella MarchiDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
Elisa GaspariniDepartment of Oncology, Arcispedale S. Maria Nuova IRCCS, 42123 Reggio Emilia, Italy.
Elena BarbieriDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
Elisabetta RazzaboniHospital Psychology Service, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
Federica DomatiDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
Federica CaggiaDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
Giovanni GrandiDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0002-3567-3278
Francesca CombiDepartment of Biomedical, Metabolic and Neural Sciences, International Doctorate School in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0001-7780-2851
Giovanni TazzioliDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Massimo DominiciDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
Enrico TagliaficoDepartment of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0003-0981-2542
Laura CortesiDepartment of Oncology and Hematology, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.ORCID 0000-0001-8950-8561
University of Modena and Reggio Emilia · ITAzienda Ospedaliero-Universitaria di Modena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common breast cancer (BC) susceptibility genes beyond

Indexed as

Germ-Line MutationHeterozygoteAtaxia Telangiectasia Mutated ProteinsBreast NeoplasmsCheckpoint Kinase 2FemaleGene FrequencyHumansPhenotypeAtaxia Telangiectasia Mutated ProteinsATM protein, humanCheckpoint Kinase 2CHEK2 protein, humanATMbilateral tumorbreast cancerCHEK2genetic testingmastectomy

Identifiers

PMID33919281
PMCPMC8143279
OpenAlexW3156039908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.