Evidence map›Paper›PMID 33919266›Full record

ReviewPharmaceutics2021

Photodynamic Therapy as an Oxidative Anti-Tumor Modality: Negative Effects of Nitric Oxide on Treatment Efficacy.

Albert W Girotti, Jonathan M Fahey, Mladen Korbelik

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Pro-tumor effects of nitric oxide from stress-upregulated inducible nitric oxide synthase in anti-tumor photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
  3. Article
  4. Determinants of Photodynamic Therapy Resistance in Cancer Cells.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Albert W GirottiDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jonathan M FaheyDepartment of Pathology, University of Colorado, Aurora, CO 80045, USA.
Mladen KorbelikDepartment of Integrative Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-6162-2319
Medical College of Wisconsin · USUniversity of Colorado Anschutz Medical Campus · US

Funding

BSC FP12605Rock River FP14869U.S. Public Health Service CA70823
6 · The paper itself

Abstract

Anti-tumor photodynamic therapy (PDT) is a unique oxidative stress-based modality that has proven highly effective on a variety of solid malignancies. PDT is minimally invasive and generates cytotoxic oxidants such as singlet molecular oxygen (

Indexed as

BET inhibitorsBET proteinsbystander effectsinducible nitric oxide synthasephotodynamic therapyphotooxidative stress nitric oxidesinglet oxygenS-nitrosationtumor cell aggressivenesstumor cell resistance

Identifiers

PMID33919266
PMCPMC8143374
OpenAlexW3153056549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.