Evidence map›Paper›PMID 33919203›Full record

ArticleJournal of personalized medicine2021

Preclinical Application of Reduced Manipulated Processing Strategy to Collect Transplantable Hepatocytes: A Pilot and Feasibility Study.

Ya-Hui Chen, Hui-Ling Chen, Cheng-Maw Ho, Hung-Yen Chen, Shu-Li Ho, Rey-Heng Hu, Po-Huang Lee, Mei-Hwei Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ya-Hui ChenHepatitis Research Center, National Taiwan University Hospital, Taipei 100, Taiwan.
Hui-Ling ChenHepatitis Research Center, National Taiwan University Hospital, Taipei 100, Taiwan.
Cheng-Maw HoHepatitis Research Center, National Taiwan University Hospital, Taipei 100, Taiwan.ORCID 0000-0003-1874-7615
Hung-Yen ChenHepatitis Research Center, National Taiwan University Hospital, Taipei 100, Taiwan.
Shu-Li HoDepartment of Anatomy and Cell Biology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Rey-Heng HuDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan.
Po-Huang LeeDepartment of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan.
Mei-Hwei ChangDepartment of Pediatrics, National Taiwan University Children Hospital, Taipei 100, Taiwan.
National Taiwan University Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

National Taiwan University Hospital 106-S3431National Taiwan University Hospital 108-S4162
6 · The paper itself

Abstract

backgroundThe complex isolation and purification process of hepatocytes for transplantation is labor intensive and with great contamination risk. Here, as a pilot and feasibility study, we examined in vitro and in vivo hepatocyte isolation feasibility and cell function of Cell Saver

methodsRat and pig liver cells were collected using this system and then cultured in vitro, and their hepatocyte-specific enzymes were characterized. We then transplanted the hepatocytes in an established acute liver-injured (retrorsine+D-galactosamine-treated) rat model for engraftment. Recipient rats were sacrificed 1, 2, and 4 weeks after transplantation, followed by donor-cell identification and histological, serologic, and immunohistopathological examination. To demonstrate this Cell Saver

resultsWe noted that in situ collagenase perfusion was followed by filtration, centrifugation, and collection in the Cell Saver

conclusionsCell Saver

Indexed as

cell processingcell therapyhepatocytereduced manipulated strategy

Identifiers

PMID33919203
PMCPMC8143084
OpenAlexW3156690927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.