Evidence map›Paper›PMID 33919138›Full record

ArticleMicroorganisms2021

Bovine Milk Oligosaccharides and Human Milk Oligosaccharides Modulate the Gut Microbiota Composition and Volatile Fatty Acid Concentrations in a Preclinical Neonatal Model.

Mei Wang, Marcia H Monaco, Jonas Hauser, Jian Yan, Ryan N Dilger, Sharon M Donovan

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Human milkFrontiers in nutrition · 2025
    Review
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  11. Article
  12. Interactions betweenFrontiers in nutrition · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mei WangDepartment of Food Science & Human Nutrition, University of Illinois, Urbana, IL 61801, USA.ORCID 0000-0003-0379-6633
Marcia H MonacoDepartment of Food Science & Human Nutrition, University of Illinois, Urbana, IL 61801, USA.ORCID 0000-0003-1677-7773
Jonas HauserSociété des Produits Nestlé SA, 1000 Lausanne, Switzerland.
Jian YanNestlé Product Technology Center Nutrition, CH-1800 Vevey, Switzerland.
Ryan N DilgerDepartment of Animal Sciences and the Piglet Nutrition and Cognition Laboratory, University of Illinois, Urbana, IL 61801, USA.ORCID 0000-0003-2538-2845
Sharon M DonovanDepartment of Food Science & Human Nutrition, University of Illinois, Urbana, IL 61801, USA.ORCID 0000-0002-9785-4189
University of Illinois Urbana-Champaign · USNestlé (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Milk oligosaccharides (OS) shape microbiome structure and function, but their relative abundances differ between species. Herein, the impact of the human milk oligosaccharides (HMO) (2'-fucosyllactose [2'FL] and lacto-N-neotetraose [LNnT]) and OS isolated from bovine milk (BMOS) on microbiota composition and volatile fatty acid (VFA) concentrations in ascending colon (AC) contents and feces was assessed. Intact male piglets received diets either containing 6.5 g/L BMOS (n = 12), 1.0 g/L 2'FL + 0.5 g/L LNnT (HMO; n = 12), both (HMO + BMOS; n = 10), or neither (CON; n = 10) from postnatal day (PND) 2 to 34. Microbiota were assessed by 16S rRNA gene sequencing and real-time PCR, and VFA were measured by gas chromatography. The microbiota was affected by OS in an intestine region-specific manner. BMOS reduced (

Indexed as

2′fucosyllactosegut microbiotalacto-N-neotetraosemilk oligosaccharidevolatile fatty acid

Identifiers

PMID33919138
PMCPMC8143120
OpenAlexW3155471767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.