Evidence map›Paper›PMID 33919123›Full record

ArticleInternational journal of molecular sciences2021

Mesenchymal Stromal Cell Therapy in Novel Porcine Model of Diffuse Liver Damage Induced by Repeated Biliary Obstruction.

Lucie Vištejnová, Václav Liška, Arvind Kumar, Jana Křečková, Ondřej Vyčítal, Jan Brůha, Jan Beneš, Yaroslav Kolinko, Tereza Blassová, Zbyněk Tonar and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Regenerative Medicine: Role of Stem Cells and Innovative Biomaterials 2.0.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Lucie VištejnováBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Václav LiškaBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Arvind KumarBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Jana KřečkováBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Ondřej VyčítalBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Jan BrůhaBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Jan BenešBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Yaroslav KolinkoBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.ORCID 0000-0003-2374-5446
Tereza BlassováBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Zbyněk TonarBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.ORCID 0000-0002-7200-9894
Michaela BrychtováBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Marie KarlíkováBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Jaroslav RacekDepartment of Clinical Biochemistry and Hematology, Medical School and Teaching Hospital in Pilsen, Charles University, Alej Svobody 80, 304 60 Pilsen, Czech Republic.ORCID 0000-0002-2868-0269
Hynek MírkaBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Petr HošekBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.ORCID 0000-0002-9359-4770
Daniel LysákBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.ORCID 0000-0001-9391-4247
Milena KrálíčkováBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 323 00 Pilsen, Czech Republic.
Charles University · CZ

Funding

Charles University PROGRES Q39Charles University Research Centre program UNCE/MED/006 University Center of Clinical and Experimental Liver SurgeryMinistry of Education, Youth and Sports of the Czech Republic CZ.02.1.01/0.0/0.0/17_048/0007280 Application of Modern Technologies in Medicine and IndustryMinistry of Education, Youth and Sports of the Czech Republic, financed from The European Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000787 "Fighting INfectious Diseases"
6 · The paper itself

Abstract

In liver surgery, biliary obstruction can lead to secondary biliary cirrhosis, a life-threatening disease with liver transplantation as the only curative treatment option. Mesenchymal stromal cells (MSC) have been shown to improve liver function in both acute and chronic liver disease models. This study evaluated the effect of allogenic MSC transplantation in a large animal model of repeated biliary obstruction followed by partial hepatectomy. MSC transplantation supported the growth of regenerated liver tissue after 14 days (MSC group,

Indexed as

Disease Models, AnimalAnimalsCholestasisLiver DiseasesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationSwinehepatectomymesenchymal stromal cellpig modelquantitative histologysecondary biliary cirrhosis

Identifiers

PMID33919123
PMCPMC8122325
OpenAlexW3152808021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.