Screening and Selection of a New Medium for Diosgenin Production via Microbial Biocatalysis of

Wancang Liu, Haibo Xiang, Tao Zhang, Xu Pang, Jing Su, Hongyu Liu, Baiping Ma, Liyan Yu

Abstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Isolation, Identification, and Fermentation Optimization of Phytase-Producing Bacteria and Their Effects on Soybean Seedlings.Applied biochemistry and biotechnology · 2025
Article
Potent Anti-Cancer Activity of 1-Dehydrodiosgenone from the Product of Microbial Transformation of Steroid Saponins.International journal of molecular sciences · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wancang LiuDivision for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Haibo XiangState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan 430011, China.

Tao ZhangDivision for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Xu PangDivision for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Jing SuDivision for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Hongyu LiuDivision for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Baiping MaBeijing Institute of Radiation Medicine, Beijing 100850, China.

Liyan YuDivision for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Funding

Beijing Municipal Natural Science Foundation 7174320CAMS Innovation Fund for Medical Sciences 2016-I2M-2-002Fundamental Research Funds for the Central Universities 3332020045National Major Science and Technology Projects of China 2017ZX09301072National Major Science and Technology Projects of China 2018ZX09711001-007-001National Microbial Resource Center NMRC-2020-3National Natural Science Foundation of China 32001081National Natural Science Foundation of China 81621064

6 · The paper itself

Abstract

Steroidal saponins are widely used as starting precursors and medical intermediates for the semi-/total-synthesis of hundreds of steroidal drugs. One such steroidal saponin is diosgenin, which has attracted significant attention due to the huge market demand in the pharmaceutical industry. Due to water waste and severe environmental pollution, the traditional diosgenin production process based on direct acid hydrolysis is no longer used. In this study, to develop a submerged fermentation (SmF) medium for clean diosgenin production via efficient microbial biocatalysis, the Box-Behnken design (BBD) in combination with the Plackett-Burman design (PBD) was used to determine the medium compositions for

Indexed as

Box–Behnken designDioscorea zingiberensis C. H. Wrightdiosgeninendophytic fungusFusarium strainmedium compositionsmicrobial biocatalysisPlackett–Burman designsubmerged fermentation

Identifiers

PMID33919111

DOI10.3390/ph14050390

PMCPMC8143133

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.