Evidence map›Paper›PMID 33919091›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Mechanistic Modelling Identifies and Addresses the Risks of Empiric Concentration-Guided Sorafenib Dosing.

Warit Ruanglertboon, Michael J Sorich, Ashley M Hopkins, Andrew Rowland

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Special Issue "Anticancer Drugs 2021".Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Warit RuanglertboonCollege of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0003-0540-7427
Michael J SorichCollege of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0003-1999-866X
Ashley M HopkinsCollege of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.ORCID 0000-0001-7652-4378
Andrew RowlandCollege of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.

Funding

Cancer Council South Australia 1127220Cancer Council South Australia 1159924National Breast Cancer Foundation PF-17-007
6 · The paper itself

Abstract

The primary objective of this study is to evaluate the capacity of concentration-guided sorafenib dosing protocols to increase the proportion of patients that achieve a sorafenib maximal concentration (C

Indexed as

concentration-guided dosingmodel informed dosingphysiologically based pharmacokineticssorafenib

Identifiers

PMID33919091
PMCPMC8143107

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.