Evidence map›Paper›PMID 33919088›Full record

ReviewMolecules (Basel, Switzerland)2021

Withaferin A-A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases.

Simona Bungau, Cosmin Mihai Vesa, Areha Abid, Tapan Behl, Delia Mirela Tit, Anamaria Lavinia Purza, Bianca Pasca, Laura Maghiar Todan, Laura Endres

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05535608 (The Impact of a Natural Ingredients and App Based Intervention Targeting the Nine Hallmarks of Aging on DNA Methylation), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05535608 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

The Impact of a Natural Ingredients and App Based Intervention Targeting the Nine Hallmarks of Aging on DNA Methylation

TypeinterventionalSponsorTruDiagnosticRan2022 to 2023Enrolled50ConditionsAgingArmsSRW Cel System
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Article
  3. A review of protective effects ofFrontiers in pharmacology · 2026
    Review
  4. Harnessing the Power ofMolecules (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Withaferin A and Celastrol Overwhelm Proteostasis.International journal of molecular sciences · 2023
    Review
  8. Can Ashwagandha Benefit the Endocrine System?-A Review.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Article
  11. Phytochemicals ofMicroorganisms · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Bio-Evaluation of the Wound Healing Activity ofAntioxidants (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Simona BungauDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.ORCID 0000-0003-3236-1292
Cosmin Mihai VesaDepartment of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.ORCID 0000-0001-5071-9601
Areha AbidDepartment of Food Science, Faculty of Agricultural and Food Sciences, University of Debrecen, 4032 Debrecen, Hungary.
Tapan BehlDepartment of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Delia Mirela TitDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.ORCID 0000-0002-0296-6592
Anamaria Lavinia PurzaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Bianca PascaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Laura Maghiar TodanDoctoral School of Biomedical Sciences, University of Oradea, 410073 Oradea, Romania.
Laura EndresDepartment of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.ORCID 0000-0002-3315-2364
University of Oradea · ROChitkara University · INUniversity of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Withaferin A (WFA) was identified as the most active phytocompound of the plant

Indexed as

AnimalsAntineoplastic Agents, PhytogenicHumansMolecular StructurePhytochemicalsPlant ExtractsSkinStructure-Activity RelationshipWithaniaWithanolidesAntineoplastic Agents, PhytogenicPhytochemicalsPlant Extractswithaferin AWithanolidesAyurvedic medicinedermatological disordersdermatologymelanomawithaferin AWithania somnifera

Identifiers

PMID33919088
PMCPMC8122412
OpenAlexW3153224208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.