Evidence map›Paper›PMID 33919003›Full record

ReviewVaccines2021

Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis.

Violante Di Donato, Giuseppe Caruso, Marco Petrillo, Evangelos Kontopantelis, Innocenza Palaia, Giorgia Perniola, Francesco Plotti, Roberto Angioli, Ludovico Muzii, Pierluigi Benedetti Panici and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 7 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 7 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Human papillomavirus (HPV) vaccination in women with conisation.The Cochrane database of systematic reviews · 2025
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  16. Review
  17. HPV Vaccine: An Effective but Underutilized Prevention Tool.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Violante Di DonatoDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0002-9254-5790
Giuseppe CarusoDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0001-5501-1936
Marco PetrilloGynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-0306-4328
Evangelos KontopantelisDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0001-6450-5815
Innocenza PalaiaDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.
Giorgia PerniolaDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.
Francesco PlottiDepartment of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Roberto AngioliDepartment of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Ludovico MuziiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0001-7195-9583
Pierluigi Benedetti PaniciDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy.
Giorgio BoganiDepartment of Gynecologic Oncology, IRCCS National Cancer Institute, 20133 Milan, Italy.ORCID 0000-0001-8373-8569
Policlinico Umberto I · ITUniversità Campus Bio-Medico · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Manchester · GBUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this meta-analysis was to discuss evidence supporting the efficacy of adjuvant human papillomavirus (HPV) vaccination in reducing the risk of recurrent cervical intraepithelial neoplasia (CIN) 2 or greater after surgical treatment.

methodsA systematic literature search was performed for studies reporting the impact of HPV vaccination on reducing the risk of recurrence of CIN 2+ after surgical excision. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI).

resultsEleven studies met the inclusion criteria and were selected for analysis. In total, 21,310 patients were included: 4039 (19%) received peri-operational adjuvant HPV vaccination while 17,271 (81%) received surgery alone. The recurrence of CIN 2+ after treatment was significantly lower in the vaccinated compared with the unvaccinated group (OR 0.35; 95% CI 0.21-0.56;

conclusionsHPV vaccination, in adjuvant setting, is associated with a reduced risk of recurrent CIN 1+ and CIN 2+ after surgical treatment.

Indexed as

cervical dysplasiacervical intraepithelial neoplasiaconizationHPVhuman papillomavirusLEEPvaccination

Identifiers

PMID33919003
PMCPMC8143003
OpenAlexW3156551532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.