Evidence map›Paper›PMID 33918992›Full record

SynthesisNutrients2021

Efficacy of Low-Carbohydrate Ketogenic Diet as an Adjuvant Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ya-Feng Yang, Preety Babychen Mattamel, Tanya Joseph, Jian Huang, Qian Chen, Babatunde O Akinwunmi, Casper J P Zhang, Wai-Kit Ming

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 5 countries.

Ya-Feng YangSchool of Medicine, Jinan University, Guangzhou 510632, China.ORCID 0000-0001-5688-7585
Preety Babychen MattamelSchool of Medicine, Jinan University, Guangzhou 510632, China.
Tanya JosephSchool of Medicine, Jinan University, Guangzhou 510632, China.
Jian HuangDepartment of Epidemiology and Biostatistics, School of Public Health, St Mary's Campus, Imperial College London, London W2 1PG, UK.ORCID 0000-0002-3931-5013
Qian ChenSchool of Medicine, Jinan University, Guangzhou 510632, China.
Babatunde O AkinwunmiBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Casper J P ZhangSchool of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.ORCID 0000-0003-1047-0287
Wai-Kit MingSchool of Medicine, Jinan University, Guangzhou 510632, China.
Jinan University · CNBrigham and Women's Hospital · USImperial College London · GBUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of low-carbohydrate ketogenic diet (LCKD) as an adjuvant therapy in antitumor treatment is not well established. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the efficacy of LCKD as an adjuvant therapy in antitumor treatment compared to non-ketogenic diet in terms of lipid profile, body weight, fasting glucose level, insulin, and adverse effects; Methods: In this study, databases such as PubMed, Web of Science, Scopus, CINAHL, and Cochrane trials were searched. Only RCTs that involved cancer participants that were assigned to dietary interventions including a LCKD group and a control group (any non-ketogenic dietary intervention) were selected. Three reviewers independently extracted the data, and the meta-analysis was performed using a fixed effects model or random effects model depending on the I

Indexed as

Diet, Carbohydrate-RestrictedDiet, KetogenicRandomized Controlled Trials as TopicBiomarkers, TumorBlood GlucoseBody WeightCase-Control StudiesFastingHumansInsulinLipidsNeoplasmsOdds RatioPatient SatisfactionTreatment OutcomeBiomarkers, TumorBlood GlucoseInsulinLipidsadjuvant cancer therapycancerketogenic dietlow-carbohydrate dietrandomized controlled trials

Identifiers

PMID33918992
PMCPMC8142992
OpenAlexW3156108334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.