Evidence map›Paper›PMID 33918979›Full record

ArticleCells2021

Role of Decorin in Posterior Capsule Opacification and Eye Lens Development.

Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Long Non-Coding RNACells · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shinsuke ShibataDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 9200293, Japan.
Naoko ShibataDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 9200293, Japan.
Satoshi OhtsukaMedical Research Institute, Kanazawa Medical University, Ishikawa 9200293, Japan.
Yasuo YoshitomiDepartment of Biochemistry, Kanazawa Medical University, Ishikawa 9200293, Japan.ORCID 0000-0002-9935-5324
Etsuko KiyokawaDepartment of Oncogenic Pathology, Kanazawa Medical University, Ishikawa 9200293, Japan.ORCID 0000-0002-0326-0479
Hideto YonekuraDepartment of Biochemistry, Kanazawa Medical University, Ishikawa 9200293, Japan.
Dhirendra P SinghDepartment of Ophthalmology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Hiroshi SasakiDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 9200293, Japan.
Eri KuboDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 9200293, Japan.ORCID 0000-0001-6789-9311
Kanazawa Medical University · JPUniversity of Nebraska Medical Center · US

Funding

Regulation and Function of Prdx6 in eye lens during Aging & Oxidative StressR01EY024589 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SINGH, DHIRENDRA P · 2014 to 2018
$1.9M
Japan Society for the Promotion of Science C 23592588NEI NIH HHS EY024589NEI NIH HHS R01 EY024589
6 · The paper itself

Abstract

Decorin (DCN) is involved in a variety of physiological and pathological processes. Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) has been proposed as a major cause for the development of posterior capsule opacification (PCO) after cataract surgery. We investigated the plausible target gene(s) that suppress PCO. The expression of

Indexed as

AgingAnimalsAqueous HumorCapsule OpacificationCataractDecorinDisease Models, AnimalDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionFibroblast Growth FactorsFibroblastsGene Expression ProfilingGene OntologyHumansLens, CrystallineDecorinFibroblast Growth FactorsTpm1 protein, mouseTransforming Growth Factor beta2TropomyosinDecorinepithelial-mesenchymal transitionlens developmentposterior capsule opacificationwound healing

Identifiers

PMID33918979
PMCPMC8070370
OpenAlexW3153170241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.