Evidence map›Paper›PMID 33918903›Full record

ArticleJournal of clinical medicine2021

Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow's Milk Protein Allergy.

María Roca, Ester Donat, Ana Rodriguez Varela, Eva Carvajal, Francisco Cano, Ana Armisen, Helena Ekoff, Antonio José Cañada-Martínez, Niclas Rydell, Carmen Ribes-Koninckx

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Observational
  13. Review
  14. Can fecal calprotectin levels be used to monitor infant milk protein allergies?Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

María RocaCeliac Disease and Digestive Immunopathology Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.ORCID 0000-0001-8157-2446
Ester DonatCeliac Disease and Digestive Immunopathology Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.ORCID 0000-0002-0114-6445
Ana Rodriguez VarelaPediatrics, Primary Health Care Center of Betera, 46117 Valencia, Spain.ORCID 0000-0002-1156-3947
Eva CarvajalDepartment of Paediatrics, Hospital Casa de Salud, 46021 Valencia, Spain.
Francisco CanoPediatrics, Primary Health Care Center of Betera, 46117 Valencia, Spain.
Ana ArmisenPediatrics, Primary Health Care Center of Betera, 46117 Valencia, Spain.
Helena EkoffThermo Fisher Scientific, 754 50 Uppsala, Sweden.
Antonio José Cañada-MartínezBiostatistics Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.ORCID 0000-0003-0635-4961
Niclas RydellThermo Fisher Scientific, 754 50 Uppsala, Sweden.
Carmen Ribes-KoninckxCeliac Disease and Digestive Immunopathology Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.
Hospital Universitari i Politècnic La Fe · ESInstituto de Investigación Sanitaria La Fe · ESThermo Fisher Scientific (Sweden) · SEHospital Casa de Salud · ES

Funding

Thermo Fisher Scientific NA
6 · The paper itself

Abstract

Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow's milk protein allergy (CMPA) and for monitoring the infants' response to a non-IgE mediated cow's milk protein (CMP)-free diet. We prospectively recruited infants aged 0 to 9 months. Stool samples were taken from 30 infants with CMPA, 19 with mild functional gastrointestinal disorders, 28 healthy infants, and 28 children who presented mild infections. Despite the fact that levels of fCP and fEDN in CMPA infants were higher than in healthy infants at month 0, differences for both parameters did not reach statistical significance (

Indexed as

eosinophil-derived neurotoxinfecal calprotectinnon-IgE-mediated cow’s milk protein allergy

Identifiers

PMID33918903
PMCPMC8069369
OpenAlexW3153163891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.