Evidence map›Paper›PMID 33918814›Full record

ArticleMolecules (Basel, Switzerland)2021

Novel Semi-Synthetic Cu (II)-Cardamonin Complex Exerts Potent Anticancer Activity against Triple-Negative Breast and Pancreatic Cancer Cells via Inhibition of the Akt Signaling Pathway.

Md Shahadat Hossan, Mohammed Khaled Bin Break, Tracey D Bradshaw, Hilary M Collins, Christophe Wiart, Teng-Jin Khoo, Ahmed Alafnan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Md Shahadat HossanSchool of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.ORCID 0000-0001-6136-6741
Mohammed Khaled Bin BreakDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81411, Saudi Arabia.ORCID 0000-0002-6031-4154
Tracey D BradshawSchool of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Hilary M CollinsSchool of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Christophe WiartCentre for Natural and Medicinal Product Research, School of Pharmacy, University of Nottingham Malaysia, Semenyih 43500, Malaysia.
Teng-Jin KhooCentre for Natural and Medicinal Product Research, School of Pharmacy, University of Nottingham Malaysia, Semenyih 43500, Malaysia.
Ahmed AlafnanDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 81411, Saudi Arabia.
University of Nottingham · GBUniversity of Ha'il · SAUniversity of Nottingham Malaysia Campus · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardamonin is a polyphenolic natural product that has been shown to possess cytotoxic activity against a variety of cancer cell lines. We previously reported the semi-synthesis of a novel Cu (II)-cardamonin complex (

Indexed as

Signal TransductionAdaptor Proteins, Signal TransducingAntineoplastic AgentsApoptosisCaspasesCell Cycle CheckpointsCell Cycle ProteinsCell Line, TumorCell MovementCell ProliferationChalconesCoordination ComplexesCopperCytoskeletonDNA DamageDown-RegulationAdaptor Proteins, Signal TransducingAntineoplastic AgentscardamoninCaspasesCell Cycle ProteinsChalconesCoordination ComplexesCopperEIF4EBP1 protein, humanH2AX protein, humanHistonesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycReactive Oxygen SpeciesAktcardamonincomplexcytotoxicity

Identifiers

PMID33918814
PMCPMC8069646
OpenAlexW3132662777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.