Evidence map›Paper›PMID 33918707›Full record

ArticleSensors (Basel, Switzerland)2021

Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis.

Saw-Lin Oo, Shishir Venkatesh, Vaithinathan Karthikeyan, Clement Manohar Arava, Spoorthy Pathikonda, Peter K N Yu, Terrence C K Lau, Xianfeng Chen, Vellaisamy A L Roy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Saw-Lin OoState Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China.ORCID 0000-0001-7371-9305
Shishir VenkateshState Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China.
Vaithinathan KarthikeyanState Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China.ORCID 0000-0001-6734-8448
Clement Manohar AravaState Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China.
Spoorthy PathikondaDepartment of Physics, City University of Hong Kong, Kowloon, Hong Kong, China.
Peter K N YuDepartment of Physics, City University of Hong Kong, Kowloon, Hong Kong, China.
Terrence C K LauDepartment of Biomedical Science, City University of Hong Kong, Kowloon, Hong Kong, China.ORCID 0000-0002-7505-7306
Xianfeng ChenInstitute for Bioengineering, School of Engineering, The University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JL, UK.ORCID 0000-0002-3189-2756
Vellaisamy A L RoyJames Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
City University of Hong Kong · HKUniversity of Edinburgh · GBUniversity of Glasgow · GB

Funding

RGC of HKSAR T42-103/16N
6 · The paper itself

Abstract

Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAU

Indexed as

CarcinomaStomach NeoplasmsAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCarcinoembryonic AntigenCost-Benefit AnalysisEarly Detection of CancerHumansAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCarcinoembryonic Antigencancer antigencancer early detectionelectrical current sensorOligo RNApolycarbonate membrane

Identifiers

PMID33918707
PMCPMC8069728
OpenAlexW3155323366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.