Evidence map›Paper›PMID 33918662›Full record

ReviewJournal of personalized medicine2021

Proton Therapy for Partial Breast Irradiation: Rationale and Considerations.

J Isabelle Choi, Jana Fox, Richard Bakst, Shaakir Hasan, Robert H Press, Arpit M Chhabra, Brian Yeh, Charles B Simone, Oren Cahlon

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

J Isabelle ChoiMemorial Sloan Kettering Cancer Center, Department of Radiation Oncology, New York, NY 10065, USA.
Jana FoxNew York Proton Center, New York, NY 10035, USA.
Richard BakstNew York Proton Center, New York, NY 10035, USA.
Shaakir HasanNew York Proton Center, New York, NY 10035, USA.
Robert H PressNew York Proton Center, New York, NY 10035, USA.ORCID 0000-0002-3297-3945
Arpit M ChhabraNew York Proton Center, New York, NY 10035, USA.
Brian YehNew York Proton Center, New York, NY 10035, USA.
Charles B SimoneMemorial Sloan Kettering Cancer Center, Department of Radiation Oncology, New York, NY 10065, USA.ORCID 0000-0002-0867-3694
Oren CahlonMemorial Sloan Kettering Cancer Center, Department of Radiation Oncology, New York, NY 10065, USA.
New York Proton Center · USMemorial Sloan Kettering Cancer Center · USMontefiore Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NIH HHS P30-CA008748
6 · The paper itself

Abstract

In an era of continued advancements in personalized medicine for the treatment of breast cancer, select patients with early stage breast cancer may be uniquely poised to benefit from partial breast irradiation (PBI) delivered with proton therapy. PBI presents an opportunity to improve quality of life during treatment with a significantly shorter treatment duration. By targeting less non-target breast tissue, excess radiation exposure and resulting toxicities are also reduced. Proton therapy represents a precision radiotherapy technology that builds on these advantages by further limiting the normal tissue exposure to unnecessary radiation dose not only to uninvolved breast tissue but also the underlying thoracic organs including the heart and lungs. Herein, we present a concise review of the rationale for the use of proton therapy for PBI, evidence available to date, and practical considerations in the implementation and use of proton therapy for this indication.

Indexed as

breast cancerpartial breast irradiationprecision medicineproton therapyradiation therapy

Identifiers

PMID33918662
PMCPMC8069416
OpenAlexW3153814443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.