Evidence map›Paper›PMID 33918635›Full record

ReviewPharmaceutics2021

Advances in Lipid-Based Nanoparticles for Cancer Chemoimmunotherapy.

Tianqi Wang, Yusuke Suita, Saradha Miriyala, Jordan Dean, Nikos Tapinos, Jie Shen

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Lipid Nanoparticles for the Delivery of mRNA.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Resveratrol-LoadedInternational journal of molecular sciences · 2023
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Nanoparticles Loaded with Platinum Drugs for Colorectal Cancer Therapy.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianqi WangDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA.
Yusuke SuitaLaboratory of Cancer Epigenetics and Plasticity, Brown University, Rhode Island Hospital, Providence, RI 02903, USA.ORCID 0000-0002-8387-4162
Saradha MiriyalaLaboratory of Cancer Epigenetics and Plasticity, Brown University, Rhode Island Hospital, Providence, RI 02903, USA.
Jordan DeanDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA.
Nikos TapinosLaboratory of Cancer Epigenetics and Plasticity, Brown University, Rhode Island Hospital, Providence, RI 02903, USA.
Jie ShenDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA.

Funding

Role of m6A RNA methylation in Regulation of Translation in Human GlioblastomaR21CA235415 · NCI · RHODE ISLAND HOSPITAL · PI TAPINOS, NIKOLAOS · 2019 to 2020
$403k
NCI NIH HHS R21CA235415Warren Alpert Foundation Grant 2019
6 · The paper itself

Abstract

Nanomedicines have shown great potential in cancer therapy; in particular, the combination of chemotherapy and immunotherapy (namely chemoimmunotherapy) that is revolutionizing cancer treatment. Currently, most nanomedicines for chemoimmunotherapy are still in preclinical and clinical trials. Lipid-based nanoparticles, the most widely used nanomedicine platform in cancer therapy, is a promising delivery platform for chemoimmunotherapy. In this review, we introduce the commonly used immunotherapy agents and discuss the opportunities for chemoimmunotherapy mediated by lipid-based nanoparticles. We summarize the clinical trials involving lipid-based nanoparticles for chemoimmunotherapy. We also highlight different chemoimmunotherapy strategies based on lipid-based nanoparticles such as liposomes, nanodiscs, and lipid-based hybrid nanoparticles in preclinical research. Finally, we discuss the challenges that have hindered the clinical translation of lipid-based nanoparticles for chemoimmunotherapy, and their future perspectives.

Indexed as

cancer therapychemoimmunotherapyimmunotherapylipid-based nanoparticlesliposomes

Identifiers

PMID33918635
PMCPMC8069739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.