Evidence map›Paper›PMID 33918623›Full record

ArticleInternational journal of molecular sciences2021

Thiosemicarbazide Derivatives Decrease the ATPase Activity of

Aleksandra Kowalczyk, Agata Paneth, Damian Trojanowski, Piotr Paneth, Jolanta Zakrzewska-Czerwińska, Paweł Stączek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Aleksandra KowalczykDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland.ORCID 0000-0001-9607-7173
Agata PanethDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0002-8198-7702
Damian TrojanowskiDepartment of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Piotr PanethInstitute of Applied Radiation Chemistry, Łódź University of Technology, Żeromskiego 116, 90-924 Łódź, Poland.ORCID 0000-0002-3091-8387
Jolanta Zakrzewska-CzerwińskaDepartment of Molecular Microbiology, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Paweł StączekDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland.ORCID 0000-0003-4416-8289
University of Łódź · PLUniversity of Wrocław · PLLodz University of Technology · PLMedical University of Lublin · PL

Funding

Narodowe Centrum Nauki OPUS 2017/25/B/NZ1/00657Narodowe Centrum Nauki UMO-2012/05/D/NZ7/02278Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki B2011000000038.01
6 · The paper itself

Abstract

Compounds targeting bacterial topoisomerases are of interest for the development of antibacterial agents. Our previous studies culminated in the synthesis and characterization of small-molecular weight thiosemicarbazides as the initial prototypes of a novel class of gyrase and topoisomerase IV inhibitors. To expand these findings with further details on the mode of action of the most potent compounds, enzymatic studies combined with a molecular docking approach were carried out, the results of which are presented herein. The biochemical assay for 1-(indol-2-oyl)-4-(4-nitrophenyl) thiosemicarbazide (

Indexed as

Anti-Bacterial AgentsBinding SitesDNA GyraseEnzyme InhibitorsHumansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationMycobacterium smegmatisProtein BindingSemicarbazidesStaphylococcus aureusStructure-Activity RelationshipTopoisomerase InhibitorsAnti-Bacterial AgentsDNA GyraseEnzyme InhibitorsSemicarbazidesthiosemicarbazideTopoisomerase Inhibitorsantibacterial agentsbacterial type IIA topoisomerasesDNA replicationmolecular modellingthiosemicarbazidestime-lapse microfluidic microscopy

Identifiers

PMID33918623
PMCPMC8069432
OpenAlexW3152956700

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.