Evidence map›Paper›PMID 33918492›Full record

ArticleMolecules (Basel, Switzerland)2021

Myorelaxant Effect of the

Luiz Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Renata Evaristo Rodrigues da Silva, Luís Pereira-de-Morais, Fernanda Maria Silva, Roger Henrique Sousa da Costa, Lindaiane Bezerra Rodrigues Dantas, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Grażyna Kowalska and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Antibacterial and Antioxidant Activity ofAntibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Luiz Jardelino de Lacerda NetoDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.ORCID 0000-0002-9339-3215
Andreza Guedes Barbosa RamosDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Renata Evaristo Rodrigues da SilvaDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Luís Pereira-de-MoraisDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Fernanda Maria SilvaDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Roger Henrique Sousa da CostaDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Lindaiane Bezerra Rodrigues DantasDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
José Galberto Martins da CostaDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Henrique Douglas Melo CoutinhoDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.ORCID 0000-0002-6634-4207
Grażyna KowalskaDepartment of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland.ORCID 0000-0002-1872-2381
Joanna HawlenaDepartment of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland.
Radosław KowalskiDepartment of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, 8 Skromna Street, 20-704 Lublin, Poland.ORCID 0000-0003-3063-8710
Roseli BarbosaDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Francisco Assis Bezerra da CunhaDepartment of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil.
Universidade Regional do Cariri · BRUniversity of Life Sciences in Lublin · PL

Funding

Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico FUNCAP (BP3-0139-00077.01.00/18)
6 · The paper itself

Abstract

purposeAlternative methods for the use of animals in research have gained increasing importance, due to assessments evaluating the real need for their use and the development of legislation that regulates the subject. The principle of the 3R's (replacement, reduction and refinement) has been an important reference, such that in vitro, ex vivo and cord replacement methods have achieved a prominent place in research.

methodsTherefore, due to successful results from studies developed with these methods, the present study aimed to evaluate the myorelaxant effect of the

resultsThe EODa relaxed the smooth muscle of swine coronary arteries precontracted with K

conclusionsMoreover, the results reveal the possibility of using the EODa in vascular disease studies since it promoted the relaxation of the Sus scrofa domesticus coronary smooth muscle.

Indexed as

Toxicity TestsAnimalsChenopodiaceaeCoronary VesselsCyclohexane MonoterpenesDisease Models, AnimalDrosophila melanogasterMotor ActivityMuscle ContractionMuscle RelaxationOils, VolatilePhytochemicalsSerotoninSwineCyclohexane Monoterpenesgamma-terpineneOils, VolatilePhytochemicalsSerotoninessential oilmyorelaxative activitynatural producttoxicity

Identifiers

PMID33918492
PMCPMC8038241
OpenAlexW3148364594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.