ArticleAnimals : an open access journal from MDPI2021
Alkyphenol Exposure Alters Steroidogenesis in Male Lizard
Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Morpho-Functional Effects of Nonylphenol-Steroid Hormone Co-Exposure on Human Prostate PNT1A Cells.Toxics · 2026Article
- Risk Assessment Arising from the Exposure of Terrestrial Vertebrates to Soil Contamination: Learning from Field Lizards of theJournal of xenobiotics · 2025Review
- Could Exposure to Glyphosate Pose a Risk to the Survival of Wild Animals? A Case Study on the Field LizardVeterinary sciences · 2023Review
- Glyphosate Interference in Follicular Organization in the Wall LizardInternational journal of molecular sciences · 2023Article
- The Italian Wall LizardInternational journal of molecular sciences · 2022Review
- Expression and Characterization of theAnimals : an open access journal from MDPI · 2022Article
- Aquatic Pollution and Risks to Biodiversity: The Example of Cocaine Effects on the Ovaries ofAnimals : an open access journal from MDPI · 2022Article
- Differential Distribution and Activity Profile of Acylpeptide Hydrolase in the Rat Seminiferous Epithelium.Biomedicines · 2022Article
- Molecular and Histological Effects of Glyphosate on Testicular Tissue of the LizardInternational journal of molecular sciences · 2022Article
- Toxic Effects on Thyroid Gland of Male Adult Lizards (International journal of molecular sciences · 2022Article
- Article
- A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals.Frontiers in endocrinology · 2022Review
- Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland.International journal of environmental research and public health · 2021Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNonylphenol (NP) and Octylphenol (OP) are persistent and non-biodegradable environmental contaminants classified as endocrine disruptor chemicals (EDCs). These compounds are widely used in several industrial applications and present estrogen-like properties, which have extensively been studied in aquatic organisms. The present study aimed to verify the interference of these compounds alone, and in mixture, on the reproductive cycle of the male terrestrial vertebrate
methodsMale lizards have been treated with different injections of both NP and OP alone and in mixture, and evaluation has been carried out using a histological approach.
resultsResults obtained showed that both substances are able to alter both testis histology and localization of key steroidogenic enzymes, such as 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β- hydroxysteroid dehydrogenase (17β-HSD) and P450 aromatase. Moreover, OP exerts a preponderant effect, and the P450 aromatase represents the major target of both chemicals.
conclusionsIn conclusion, NP and OP inhibit steroidogenesis, which in turn may reduce the reproductive capacity of the specimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.