ReviewJournal of clinical medicine2021
Body Mass Index Reduction and Selected Cardiometabolic Risk Factors in Obstructive Sleep Apnea: Meta-Analysis.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.Cardiovascular diabetology · 2024Pooled it
- Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Integrated Assessment of Obesity Indices and Novel Inflammatory Biomarkers in Predicting the Severity of Obstructive Sleep Apnea.Journal of clinical medicine · 2025Article
- Management of Adult Obstructive Sleep Apnoea: Many Questions, Not Enough Answers!Journal of sleep research · 2025Review
- The Predictive Value of the Triponderal Mass Index in Adult Obstructive Sleep Apnea Severity.Journal of clinical practice and research · 2025Article
- Associations Among Cardiometabolic Risk Factors, Sleep Duration, and Obstructive Sleep Apnea in a Southeastern US Rural Community: Cross-Sectional Analysis From the SLUMBRx-PONS Study.JMIR formative research · 2024Observational
- A Dietary and Lifestyle Intervention Improves Treatment Adherence and Clinical Outcomes in Overweight and Obese Patients with Obstructive Sleep Apnea: A Randomized, Controlled Trial.Life (Basel, Switzerland) · 2023Article
- Clinical evaluation of patients living with obesity.Internal and emergency medicine · 2023Review
- Body weight and obstructive sleep apnea: a mathematical relationship between body mass index and apnea-hypopnea index in veterans.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- The Automatic Algorithm of the Auto-CPAP Device as a Tool for the Assessment of the Treatment Efficacy of CPAP in Patients with Moderate and Severe Obstructive Sleep Apnea Syndrome.Life (Basel, Switzerland) · 2022Article
- Current and novel treatment options for obstructive sleep apnoea.ERJ open research · 2022Review
- Obstructive sleep apnea therapy for cardiovascular risk reduction-Time for a rethink?Clinical cardiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although clinical studies have been carried out on the effects of weight reduction in sleep apnea patients, no direct link has been shown between weight reduction and changes in cardio-metabolic risk factors. We aimed to analyze changes in the apnea-hypopnea index and selected cardio-metabolic parameters (total cholesterol, triglycerides, glucose, insulin, blood pressure) in relation to the reduction in body mass index in obstructive sleep apnea patients. Medline, Web of Science and Cochrane databases were searched to combine results from individual studies in a single meta-analysis. We identified 333 relevant articles, from which 30 papers were assigned for full-text review, and finally 10 (seven randomized controlled trials and three nonrandomized studies) were included for data analysis. One unit of body mass index reduction was found to significantly influence changes in the apnea-hypopnea index (-2.83/h; 95% CI: -4.24, -1.41), total cholesterol (-0.12 mmol/L; 95% CI: -0.22, -0.01), triglycerides (-0.24 mmol/L; 95% CI: -0.46, -0.02), fasting insulin (-7.3 pmol/L; 95% CI: -11.5, -3.1), systolic (-1.86 mmHg; 95% CI: -3.57, -0.15) and diastolic blood pressure (-2.07 mmHg; 95% CI: -3.79, -0.35). Practical application of lifestyle modification resulting in the reduction of one unit of body mass index gives meaningful changes in selected cardio-metabolic risk factors in obstructive sleep apnea patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.