ReviewJournal of clinical medicine2021
Virtual Reality in Neurorehabilitation: An Umbrella Review of Meta-Analyses.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Virtual reality in neurorehabilitation for musculoskeletal disorders: a bibliometric analysis from 2010 to 2025.Frontiers in neurology · 2026Pooled it
- Effectiveness of virtual reality for functional disorders in cerebral palsy: an overview of systematic reviews and meta-analyses.Frontiers in neurology · 2025Pooled it
- Combining robot-assisted therapy with virtual reality or using it alone? A systematic review on health-related quality of life in neurological patients.Health and quality of life outcomes · 2023Pooled it
- NintendoInternational journal of environmental research and public health · 2022Pooled it
- Extended Reality in Neurosurgical Education: A Systematic Review.Sensors (Basel, Switzerland) · 2022Pooled it
- The Effect of Non-Immersive Virtual Reality Exergames versus Traditional Physiotherapy in Parkinson's Disease Older Patients: Preliminary Results from a Randomized-Controlled Trial.International journal of environmental research and public health · 2022Trial
- Virtual Reality-Assisted Rehabilitation for Adolescents with Cerebral Palsy: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Older Adults' Experiences of Commercial Virtual Reality for Stroke Rehabilitation: A Mixed-Methods Study.Medicina (Kaunas, Lithuania) · 2026Article
- Effects of Exposure to Non-Immersive Virtual Reality on Disgust and Anxiety: A Study on Non-Clinical Samples.Behavioral sciences (Basel, Switzerland) · 2026Article
- Working memory load and search efficiency in conventional monitor-based 2D versus 3D virtual settings: analysis of response times and parietal induced alpha activity in a modified Sternberg task.Experimental brain research · 2026Article
- Future trends and challenges in occupational therapy: Insights from a Delphi study.The British journal of occupational therapy · 2026Article
- Clinical implementation of virtual reality in neurorehabilitation: a scoping review of barriers, facilitators, and motivational factors.Frontiers in rehabilitation sciences · 2026Review
- Inflammatory profiling for precision neurorehabilitation after traumatic brain injury and stroke: a narrative review.Frontiers in neurology · 2026Review
- Effects of Exergame with Biofeedback Training on Functional Status, Cognition, and Quality of Life in Outpatients with Polyneuropathies: A Longitudinal Pilot Study.Brain sciences · 2025Article
- Domain-Specific Evaluation of Exergame Metrics Among Older Adults With Mild Neurocognitive Disorder: Secondary Analysis of 2 Randomized Controlled Trials.JMIR serious games · 2025Article
- Efficacy of Neurorehabilitation Approaches in Traumatic Brain Injury Patients: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Telerehabilitation and Its Impact Following Stroke: An Umbrella Review of Systematic Reviews.Journal of clinical medicine · 2024Review
- Virtual reality-guided therapy on a stroke unit: a feasibility study.Neurological research and practice · 2024Article
- Article
- Extended Reality-Based Head-Mounted Displays for Surgical Education: A Ten-Year Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological disorders are a leading cause of death and disability worldwide. Can virtual reality (VR) based intervention, a novel technology-driven change of paradigm in rehabilitation, reduce impairments, activity limitations, and participation restrictions? This question is directly addressed here for the first time using an umbrella review that assessed the effectiveness and quality of evidence of VR interventions in the physical and cognitive rehabilitation of patients with stroke, traumatic brain injury and cerebral palsy, identified factors that can enhance rehabilitation outcomes and addressed safety concerns. Forty-one meta-analyses were included. The data synthesis found mostly low- or very low-quality evidence that supports the effectiveness of VR interventions. Only a limited number of comparisons were rated as having moderate and high quality of evidence, but overall, results highlight potential benefits of VR for improving the ambulation function of children with cerebral palsy, mobility, balance, upper limb function, and body structure/function and activity of people with stroke, and upper limb function of people with acquired brain injury. Customization of VR systems is one important factor linked with improved outcomes. Most studies do not address safety concerns, as only nine reviews reported adverse effects. The results provide critical recommendations for the design and implementation of future VR programs, trials and systematic reviews, including the need for high quality randomized controlled trials to test principles and mechanisms, in primary studies and in meta-analyses, in order to formulate evidence-based guidelines for designing VR-based rehabilitation interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.