ReviewCells2021
The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies.
Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Brain Volumetric Changes Post-COVID-19: A Systematic Review.Brain sciences · 2025Review
- Article
- Review
- A Comparative Analysis of the Ocular Microbiome: Insights into Healthy Eyes and Anophthalmic Sockets.Microorganisms · 2024Article
- Conditional reprogrammed human limbal epithelial cell model for anti-SARS-CoV-2 drug screening.Heliyon · 2024Article
- Role of the Senescence-Associated Factor Dipeptidyl Peptidase 4 in the Pathogenesis of SARS-CoV-2 Infection.Aging and disease · 2024Article
- SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure.PLoS pathogens · 2024Article
- Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger.The American journal of tropical medicine and hygiene · 2023Article
- Ocular manifestations in COVID-19 infections: a case series.Annals of medicine and surgery (2012) · 2023Article
- Long-term effects of SARS-CoV-2 infection on human brain and memory.Cell death discovery · 2023Review
- Reduced Vessel Density and Enlarged Foveal Avascular Zone in the Macula as a Result of Systemic Hypoxia Caused by SARS-CoV-2 Infection.Journal of personalized medicine · 2023Review
- Why not to pick your nose: Association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers.PloS one · 2023Article
- P4 Medicine for Heterogeneity of Dry Eye: A Mobile Health-based Digital Cohort Study.Juntendo Iji zasshi = Juntendo medical journal · 2023Review
- Detection of Airborne Influenza A and SARS-CoV-2 Virus Shedding following Ocular Inoculation of Ferrets.Journal of virology · 2022Article
- Ocular symptoms in COVID-19 infection: a survey study.Journal of ophthalmic inflammation and infection · 2022Article
- Current clinical status of new COVID-19 vaccines and immunotherapy.Environmental science and pollution research international · 2022Review
- Association of COVID-19 Infection With Wearing Glasses in a High-Prevalence Area in Denmark and Sweden.JAMA ophthalmology · 2022Article
- Women in the European Virus Bioinformatics Center.Viruses · 2022Article
- TU Delft COVID-app: A tool to democratize CFD simulations for SARS-CoV-2 infection risk analysis.The Science of the total environment · 2022Article
- Therapeutic potential of the MDM2 inhibitor Nutlin-3 in counteracting SARS-CoV-2 infection of the eye through p53 activation.Frontiers in medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem. Although the respiratory system is the main impaired organ, conjunctivitis is one of its common findings. However, it is not yet understood if SARS-CoV-2 can infect the eye and if the ocular surface can be a potential route of SARS-CoV-2 transmissions. Our review focuses on the viral entry mechanisms to give a better understanding of the interaction between SARS-CoV-2 and the eye. We highlighted findings that give evidence for multiple potential receptors of SARS-CoV-2 on the ocular surface. Additionally, we focused on data concerning the detection of viral RNA and its spike protein in the various ocular tissues from patients. However, the expression level seemed to be relatively low compared to the respiratory tissues as a result of a unique environment surrounding the ocular surface and the innate immune response of SARS-CoV-2. Nevertheless, our review suggests the ocular surface as a potential route for SARS-CoV-2 transmission, and as a result of this study we strongly recommend the protection of the eyes for ophthalmologists and patients at risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.