Evidence map›Paper›PMID 33918304›Full record

ArticleJournal of clinical medicine2021

Derivation and Validation of Essential Predictors and Risk Index for Early Detection of Diabetic Retinopathy Using Electronic Health Records.

Ru Wang, Zhuqi Miao, Tieming Liu, Mei Liu, Kristine Grdinovac, Xing Song, Ye Liang, Dursun Delen, William Paiva

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. MUSE-Net: Missingness-aware mUlti-branching Self-attention Encoder for Irregular Longitudinal Electronic Health Records.IEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2026
    Article
  3. Review
  4. Article
  5. A novel hyperparameter search approach for accuracy and simplicity in disease prediction risk scoring.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  6. Article
  7. Article
  8. State-of-the-Art Research on Diabetic Retinopathy.Journal of clinical medicine · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ru WangDepartment of Statistics, Oklahoma State University, Stillwater, OK 74078, USA.
Zhuqi MiaoCenter for Health Systems Innovation, Oklahoma State University, Tulsa, OK 74119, USA.
Tieming LiuSchool of Industrial Engineering and Management, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0001-8104-2701
Mei LiuDivision of Medical Informatics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Kristine GrdinovacDivision of Endocrinology, Metabolism, and Genetics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Xing SongDepartment of Health Management and Informatics, University of Missouri, Columbia, MO 65212, USA.
Ye LiangDepartment of Statistics, Oklahoma State University, Stillwater, OK 74078, USA.
Dursun DelenCenter for Health Systems Innovation, Oklahoma State University, Tulsa, OK 74119, USA.
William PaivaCenter for Health Systems Innovation, Oklahoma State University, Tulsa, OK 74119, USA.

Funding

Foundation for the National Institutes of Health UL1TR002366Oklahoma Center for the Development of Science & Technology (OCAST) HR 18-087-1
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a leading cause for blindness among working-aged adults. The growing prevalence of diabetes urges for cost-effective tools to improve the compliance of eye examinations for early detection of DR. The objective of this research is to identify essential predictors and develop predictive technologies for DR using electronic health records. We conducted a retrospective analysis on a derivation cohort with 3749 DR and 94,127 non-DR diabetic patients. In the analysis, an ensemble predictor selection method was employed to find essential predictors among 26 variables in demographics, duration of diabetes, complications and laboratory results. A predictive model and a risk index were built based on the selected, essential predictors, and then validated using another independent validation cohort with 869 DR and 6448 non-DR diabetic patients. Out of the 26 variables, 10 were identified to be essential for predicting DR. The predictive model achieved a 0.85 AUC on the derivation cohort and a 0.77 AUC on the validation cohort. For the risk index, the AUCs were 0.81 and 0.73 on the derivation and validation cohorts, respectively. The predictive technologies can provide an early warning sign that motivates patients to comply with eye examinations for early screening and potential treatments.

Indexed as

diabetic retinopathyearly detectionelectronic health recordspredictive modelspredictor selectionrisk index

Identifiers

PMID33918304
PMCPMC8038185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.