Evidence map›Paper›PMID 33918166›Full record

ArticleViruses2021

Molecular Characterization of Closely Related H6N2 Avian Influenza Viruses Isolated from Turkey, Egypt, and Uganda.

Yavuz Mercan, Gladys Atim, Ahmed E Kayed, M Ekin Azbazdar, Ahmed Kandeil, Mohamed A Ali, Adam Rubrum, Pamela McKenzie, Richard J Webby, Bernard Erima and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 6 countries.

Yavuz MercanEmerging Viral Diseases Laboratory, Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.ORCID 0000-0001-5582-7521
Gladys AtimMakerere University Walter Reed Project, P.O. Box 7062 Kampala, Uganda.
Ahmed E KayedCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12311, Egypt.
M Ekin AzbazdarEmerging Viral Diseases Laboratory, Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.
Ahmed KandeilCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12311, Egypt.ORCID 0000-0003-3253-6961
Mohamed A AliCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12311, Egypt.ORCID 0000-0002-5615-3212
Adam RubrumSt Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pamela McKenzieSt Jude Children's Research Hospital, Memphis, TN 38105, USA.
Richard J WebbySt Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bernard ErimaMakerere University Walter Reed Project, P.O. Box 7062 Kampala, Uganda.
Fred Wabwire-MangenMakerere University Walter Reed Project, P.O. Box 7062 Kampala, Uganda.
Qouilazoni A UkuliMakerere University Walter Reed Project, P.O. Box 7062 Kampala, Uganda.
Titus TugumeMakerere University Walter Reed Project, P.O. Box 7062 Kampala, Uganda.
Denis K ByarugabaMakerere University Walter Reed Project, P.O. Box 7062 Kampala, Uganda.
Ghazi KayaliDepartment of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas, Houston, TX 77030, USA.
Mariette F DucatezIHAP, UMR1225, Université de Toulouse, INRAe, ENVT, 31076 Toulouse, France.
Zeynep A KoçerEmerging Viral Diseases Laboratory, Izmir Biomedicine and Genome Center, 35340 Izmir, Turkey.ORCID 0000-0001-9178-0142
Makerere University Walter Reed Project · UGIzmir University · TRNational Research Centre · EGSt. Jude Children's Research Hospital · USÉcole Nationale Vétérinaire de Toulouse · FRThe University of Texas Health Science Center at Houston · US

Funding

NIAID NIH HHS HHSN272201400006C
6 · The paper itself

Abstract

Genetic analysis of circulating avian influenza viruses (AIVs) in wild birds at different geographical regions during the same period could improve our knowledge about virus transmission dynamics in natural hosts, virus evolution as well as zoonotic potential. Here, we report the genetic and molecular characterization of H6N2 influenza viruses isolated from migratory birds in Turkey, Egypt, and Uganda during 2017-2018. The Egyptian and Turkish isolates were genetically closer to each other than they were to the virus isolated from Uganda. Our results also suggest that multiple reassortment events were involved in the genesis of the isolated viruses. All viruses contained molecular markers previously associated with increased replication and/or pathogenicity in mammals. The results of this study indicate that H6N2 viruses carried by migratory birds on the West Asian/East African and Mediterranean/Black Sea flyways have the potential to transmit to mammals including humans. Additionally, adaptation markers in these viruses indicate the potential risk for poultry, which also increases the possibility of human exposure to these viruses.

Indexed as

PhylogenyAnimal MigrationAnimalsAnimals, WildChickensEgyptGenome, ViralHumansInfluenza A virusInfluenza in BirdsPoultryReassortant VirusesTurkeyUgandaavian influenza virusmigratory birdsmolecular markersreassortmentwaterfowl

Identifiers

PMID33918166
PMCPMC8065897
OpenAlexW3141250923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.