ArticlePlants (Basel, Switzerland)2021
Bitter Melon (
Article in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review.Frontiers in pharmacology · 2023Pooled it
- The Biochemical Role of Bitter Melon (Food science & nutrition · 2026Article
- Nutritional Impact on Breast Cancer in Menopausal and Post-Menopausal Patients Treated with Aromatase Inhibitors.Cancers · 2025Review
- Review
- The Role of Community Organisation, Religion, Spirituality and Cultural Beliefs on Diabetes Social Support and Self-Management in Sub-Saharan Africa: Integrative Literature Review.Journal of religion and health · 2025Review
- Evaluation of Luffa Rootstocks to Improve Resistance in Bitter Gourd (Plants (Basel, Switzerland) · 2025Article
- Animal origins free products in cell culture media: a new frontier.Cytotechnology · 2025Review
- The consequences of fermentation metabolism on the qualitative qualities and biological activity of fermented fruit and vegetable juices.Food chemistry: X · 2024Review
- Natural Functional Beverages as an Approach to Manage Diabetes.International journal of molecular sciences · 2023Review
- Efficacy of different organic and inorganic nutrient sources on the growth and yield of bitter gourd (Heliyon · 2023Article
- Antidiabetic Properties of Plant Secondary Metabolites.Metabolites · 2023Review
- Medicinal Plants and Plant-Based Remedies in Grande-Terre: An Ethnopharmacological Approach.Plants (Basel, Switzerland) · 2023Article
- Antidiabetic Potential of Plants from the Caribbean Basin.Plants (Basel, Switzerland) · 2022Review
- Review
- Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review.Frontiers in pharmacology · 2022Review
- Physicochemical and Functional Characterization of Newly Designed Biopolymeric-Based Encapsulates with Probiotic Culture and Charantin.Foods (Basel, Switzerland) · 2021Article
- Double emulsion-based mayonnaise encapsulated with bitter gourd extract exhibits improvement in vivo anti-diabetic action in STZ induced rats.3 Biotech · 2021Article
- Antidiabetic Activity ofAvicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Natural products are gaining clinical significance in modern day health care systems to prevent diseases. Bitter melon, a health promoting vegetable, is traditionally used for medical nutrition therapy to cure diabetes but to reap maximum health claims, vigilant control of its substances in diet is crucial as part of curative action for effective diabetes management. In the present research, first phase focused on detection of key bioactive components, i.e., charantin and vicine in different parts of its fruit. In the second phase, normal and hyperglycemic Sprague Dawley rats were fed on skin, flesh and whole fruit of bitter melon at 150 and 300 mg/kg body weight and assessed for diabetes prophylaxis and treatment. The highest amount of charantin (0.16 ± 0.02 mg/g) was recorded in flesh while vicine was present in abundance in whole fruit (0.21 ± 0.01 μg/100 g). In normal rats, bitter melon supplementation was helpful in managing the onset of diabetes. Hyperglycemic rats showed diabetic complications including polydipsia, polyuria, glycosuria, renal hypertrophy and increased glomerular filtration rate. However, bitter melon consumption showed significant improvements in these parameters. The most potent dose was 300 mg/kg whole fruit that resulted in 31.64% lowering of blood glucose level and 27.35% increase in insulin level in hyperglycemic rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.