Evidence map›Paper›PMID 33917946›Full record

ReviewPlants (Basel, Switzerland)2021

Natural Blues: Structure Meets Function in Anthocyanins.

Alan Houghton, Ingo Appelhagen, Cathie Martin

Abstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Copigmentation of procyanidin dimers with malvidin-3-Current research in food science · 2026
    Article
  12. Dark side of anthocyanin pigmentation.Plant biology (Stuttgart, Germany) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alan HoughtonJohn Innes Centre, Department of Metabolic Biology and Biological Chemistry, Norwich Research Park, Norwich NR4 7UH, UK.ORCID 0000-0002-4732-4083
Ingo AppelhagenPhyton Biotech, Alter Postweg 1, 22926 Ahrensburg, Germany.
Cathie MartinJohn Innes Centre, Department of Metabolic Biology and Biological Chemistry, Norwich Research Park, Norwich NR4 7UH, UK.ORCID 0000-0002-3640-5080

Funding

Biotechnological and Biological Scientific Research Council (BBSRC) BB/J004596/1Biotechnological and Biological Scientific Research Council (BBSRC) BB/L014130/1Biotechnological and Biological Scientific Research Council (BBSRC) BB/P012523/1Biotechnological and Biological Scientific Research Council (BBSRC) : 031A336A0Biotechnology and Biological Sciences Research Council BB/L014130/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000153Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790
6 · The paper itself

Abstract

Choices of blue food colourants are extremely limited, with only two options in the USA, synthetic blue no. 1 and no. 2, and a third available in Europe, patent blue V. The food industry is investing heavily in finding naturally derived replacements, with limited success to date. Here, we review the complex and multifold mechanisms whereby blue pigmentation by anthocyanins is achieved in nature. Our aim is to explain how structure determines the functionality of anthocyanin pigments, particularly their colour and their stability. Where possible, we describe the impact of progressive decorations on colour and stability, drawn from extensive but diverse physico-chemical studies. We also consider briefly how this understanding could be harnessed to develop blue food colourants on the basis of the understanding of how anthocyanins create blues in nature.

Indexed as

anthocyaninblueco-pigmentfood colourantsquinonoid base

Identifiers

PMID33917946
PMCPMC8068391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.