Evidence map›Paper›PMID 33917930›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Cardiopulmonary Exercise Testing Is an Accurate Tool for the Diagnosis of Pulmonary Arterial Hypertension in Scleroderma Related Diseases.

Mattia Bellan, Ailia Giubertoni, Cristina Piccinino, Mariachiara Buffa, Debora Cromi, Daniele Sola, Roberta Pedrazzoli, Ileana Gagliardi, Elisa Calzaducca, Erika Zecca and 4 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Physical exercise for pulmonary arterial hypertension diagnosis and therapy.International journal of cardiology. Congenital heart disease · 2025
    Review
  2. Review
  3. Review
  4. Right ventricular energetic biomarkers from 4D Flow CMR are associated with exertional capacity in pulmonary arterial hypertension.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Mattia BellanDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.ORCID 0000-0003-1488-8736
Ailia GiubertoniDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Cristina Piccinino"AOU Maggiore della Carità" Hospital, 28100 Novara, Italy.
Mariachiara BuffaDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Debora CromiDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Daniele Sola"AOU Maggiore della Carità" Hospital, 28100 Novara, Italy.
Roberta Pedrazzoli"AOU Maggiore della Carità" Hospital, 28100 Novara, Italy.
Ileana GagliardiDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Elisa CalzaduccaDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Erika ZeccaDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Filippo PatruccoDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.ORCID 0000-0002-4794-8734
Giuseppe PattiDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Pier Paolo SainaghiDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.ORCID 0000-0001-8322-9158
Mario PirisiDepartment of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early diagnosis of pulmonary arterial hypertension (PAH) is a major determinant of prognosis in patients affected by connective tissue diseases (CTDs) complicated by PAH. In the present paper we investigated the diagnostic accuracy of cardiopulmonary exercise testing (CPET) in this specific setting. We recorded clinical and laboratory data of 131 patients who underwent a CPET at a pulmonary hypertension clinic. Out of them, 112 (85.5%) had a diagnosis of CTDs; 8 (6.1%) received a diagnosis of CTDs-PAH and 11 (8.4%) were affected PH of different etiology. Among CPET parameters the following parameters showed the best diagnostic performance for PAH: peak volume of oxygen uptake (VO

Indexed as

cardiopulmonary exercise testingpulmonary arterial hypertensionsclerodermasystemic sclerosis

Identifiers

PMID33917930
PMCPMC8068386
OpenAlexW3153017434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.