Evidence map›Paper›PMID 33917834›Full record

ArticleBiology2021

Insight into Liver lncRNA and mRNA Profiling at Four Developmental Stages in Ningxiang Pig.

Yan Gong, Yuebo Zhang, Biao Li, Yu Xiao, Qinghua Zeng, Kang Xu, Yehui Duan, Jianhua He, Haiming Ma

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yan GongCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yuebo ZhangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Biao LiCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yu XiaoCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Qinghua ZengCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Kang XuLaboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha 410125, China.
Yehui DuanLaboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha 410125, China.
Jianhua HeCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-9289-4405
Haiming MaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Hunan Agricultural University · CNInstitute of Subtropical Agriculture · CN

Funding

Basic Research Project of Ningxiang Pig 15073"Double first class" Construction Project of Hunan Agricultural University KXK201801004Genetic Resource Innovations and Its Application of Indigenous Pig Breeds in Hunan Province 2019NK2193Hunan Natural Science Joint Fund 2018JJ4003Hunan Science and Technology Innovation Project 72010102-30218National Natural Science Foundation of China U19A2037Strategic Priority Research Program of the Chinese Academy of Sciences XDA24030204
6 · The paper itself

Abstract

Ningxiang pigs, a fat-type pig, are native to Ningxiang County in Hunan Province, with thousands of years of breeding history. This study aims to explore the expression profiles and functional networks on messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) in the liver. Liver tissue of Ningxiang piglets was collected at 30, 90, 150, and 210 days after birth (four development stages), and the mRNA and lncRNA expression was profiled. Compared to mRNA and lncRNA expression profiles, most differentially expressed mRNAs (DEmRNAs) were upregulated at 30 days; however, most DElncRNAs were downregulated at 210 days. Via Short Time-series Expression Miner (STEM) analysis and weighted gene co-expression network analysis (WGCNA), a complex interaction between mRNAs and lncRNAs was identified, indicating that lncRNAs may be a critical regulatory element for mRNAs. One module of genes in particular (module profile 4) was related to fibril organization, vasculogenesis, GTPase activator activity, and regulation of kinase activity. The mRNAs and lncRNAs in module profile 4 had a similar pattern of expression, indicating that they have functional and regulatory relationships. Only

Indexed as

liver developmentlncRNAsmRNAsNingxiang pigSTEM

Identifiers

PMID33917834
PMCPMC8068270
OpenAlexW3142874428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.