Evidence map›Paper›PMID 33917832›Full record

ArticleCancers2021

Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer.

Shivan Sivakumar, Enas Abu-Shah, David J Ahern, Edward H Arbe-Barnes, Ashwin K Jainarayanan, Nagina Mangal, Srikanth Reddy, Aniko Rendek, Alistair Easton, Elke Kurz and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. CD39Frontiers in oncology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. CD3bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Shivan SivakumarDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Enas Abu-ShahKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.ORCID 0000-0001-5033-8171
David J AhernKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.ORCID 0000-0002-7006-7396
Edward H Arbe-BarnesUniversity of Oxford Medical School, Oxford OX1 2JD, UK.ORCID 0000-0002-2687-6567
Ashwin K JainarayananKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Nagina MangalNuffield Department of Surgical Sciences, University of Oxford, Oxford OX3 9DU, UK.
Srikanth ReddyDepartment of Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Aniko RendekDepartment of Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Alistair EastonDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0001-8148-5406
Elke KurzKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
Michael SilvaDepartment of Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Zahir SoonawallaDepartment of Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Lara R HeijDepartment of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.ORCID 0000-0002-0602-3356
Rachael Bashford-RogersWellcome Trust Centre for Human Genomics, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-6838-0711
Mark R MiddletonDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0003-0167-1685
Michael L DustinKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.ORCID 0000-0003-4983-6389
University of Oxford · GBOxford University Hospitals NHS Trust · GBCentre for Human Genetics · GBRWTH Aachen University · DE

Funding

Bristol-Myers Squibb N/AUCB UK N/AWellcome Trust 100262Z/12/Z
6 · The paper itself

Abstract

Pancreatic cancer has one of the worst prognoses of any human malignancy and leukocyte infiltration is a major prognostic marker of the disease. As current immunotherapies confer negligible survival benefits, there is a need to better characterise leukocytes in pancreatic cancer to identify better therapeutic strategies. In this study, we analysed 32 human pancreatic cancer patients from two independent cohorts. A multi-parameter mass-cytometry analysis was performed on 32,000 T-cells from eight patients. Single-cell RNA sequencing dataset analysis was performed on a cohort of 24 patients. Multiplex immunohistochemistry imaging and spatial analysis were performed to map immune infiltration into the tumour microenvironment. Regulatory T-cell populations demonstrated highly immunosuppressive states with high TIGIT, ICOS and CD39 expression. CD8

Indexed as

CD39ICOSimmune checkpointspancreatic cancerregulatory T-cellssenescent T-cellsTIGIT

Identifiers

PMID33917832
PMCPMC8068251
OpenAlexW3140946227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.