Evidence map›Paper›PMID 33917756›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Doxorubicin-Loaded Metal-Organic Frameworks Nanoparticles with Engineered Cyclodextrin Coatings: Insights on Drug Location by Solid State NMR Spectroscopy.

Xue Li, Marianna Porcino, Jingwen Qiu, Doru Constantin, Charlotte Martineau-Corcos, Ruxandra Gref

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Porous Metal-Organic Framework Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Article
  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xue LiInstitut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.ORCID 0000-0003-0254-643X
Marianna PorcinoCEMHTI UPR CNRS 3079, Université d'Orléans, 45071 Orléans, France.
Jingwen QiuInstitut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.
Doru ConstantinLaboratoire de Physique des Solides, UMR 8502, Université Paris-Sud, 91405 Orsay, France.
Charlotte Martineau-CorcosCEMHTI UPR CNRS 3079, Université d'Orléans, 45071 Orléans, France.
Ruxandra GrefInstitut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.ORCID 0000-0002-7869-0908
Université Paris-Sud · FRUniversité d'Orléans · FR

Funding

Agence Nationale de la Recherche ANR-10-LABX-0035
6 · The paper itself

Abstract

Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core-shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable γ-cyclodextrin-citrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including

Indexed as

cyclodextrindoxorubicinmetal-organic frameworks nanoparticlessolid state NMR spectroscopy

Identifiers

PMID33917756
PMCPMC8068177
OpenAlexW3150008438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.