Evidence map›Paper›PMID 33917746›Full record

ArticleBiomedicines2021

Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation.

Jinmei Wang, Xiaoxiao Wang, Jundong Xie, Bin Yao, Miaohua Mo, Danjun Ma, Chen Huang, Renhe Xu, Xiaobing Fu, Edward E Tredget and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

Jinmei WangSchool of Mechanical Engineering, Dongguan University of Technology, 1 Daxue Rd, Dongguan 523830, China.
Xiaoxiao WangiBHE, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Jundong XieiBHE, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Bin YaoiBHE, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Miaohua MoiBHE, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Danjun MaSchool of Mechanical Engineering, Dongguan University of Technology, 1 Daxue Rd, Dongguan 523830, China.
Chen HuangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Renhe XuFaculty of Health Sciences, University of Macau, Macau 999078, China.
Xiaobing FuWound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing 100088, China.
Edward E TredgetWound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, AB T6G2B7, Canada.
Yaojiong WuiBHE, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
University Town of Shenzhen · CNDongguan University of Technology · CNFirst Affiliated Hospital of Chinese PLA General Hospital · CNSouthern University of Science and Technology · CNTsinghua–Berkeley Shenzhen Institute · CNUniversity of Alberta · CAUniversity of Macau · MOXi'an Jiaotong University · CN

Funding

China Postdoctoral Science Foundation 2019M663673National Key R&D Program of China 2017YFC1103304Natural Science Foundation of China 31961160702, 81903239Shenzhen Science and Technology Innovation Committee JCYJ20180307123901314, JCYJ20190809180217220 and JCYJ20180307123807944State Key Laboratory of Chemical Oncogenomics fund State Key Laboratory of Chemical Oncogenomics fundTsinghua Shenzhen International Graduate School Overseas Cooperation Fund HW2018006
6 · The paper itself

Abstract

Currently, engineered skin substitutes (ESS) are unable to regenerate cutaneous appendages. Recent studies have shown that skin-derived precursors (SKPs), which are extensively available, have the potential to induce hair follicle neogenesis. Here, we demonstrate that ESS consisting of culture-expanded SKPs and epidermal stem cells (Epi-SCs) reconstitute the skin with hair follicle regeneration after grafting into nude mice. SKPs seeded in a C-GAG matrix proliferated and expressed higher levels of hair induction signature genes-such as

Indexed as

engineered skin substitutehair follicle neogenesisskin derived precursors

Identifiers

PMID33917746
PMCPMC8068101
OpenAlexW3156009634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.