Evidence map›Paper›PMID 33917715›Full record

ArticleMicroorganisms2021

Hippocampal Atrophy in Pediatric Transplant Recipients with Human Herpesvirus 6B.

Misa Miyake, Yoshiki Kawamura, Naoko Ishihara, Shigetaka Suzuki, Hiroki Miura, Yoko Sakaguchi, Masaharu Tanaka, Yoshiyuki Takahashi, Seiji Kojima, Hiroshi Toyama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Misa MiyakeDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Yoshiki KawamuraDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.ORCID 0000-0003-3942-7098
Naoko IshiharaDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Shigetaka SuzukiDepartment of Radiology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Hiroki MiuraDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Yoko SakaguchiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Masaharu TanakaDepartment of Radiology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Seiji KojimaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Hiroshi ToyamaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Jun NatsumeDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.ORCID 0000-0002-2081-9449
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Fujita Health University · JPNagoya University · JP

Funding

Japan Society for the Promotion of Science 19K17346Mother and Child Health Foundation 30-10
6 · The paper itself

Abstract

The aim of this study was to determine whether human herpesvirus 6B (HHV-6B) infection can impair the hippocampus in pediatric hematopoietic stem cell transplant (HSCT) recipients. Study subjects were pediatric HSCT recipients monitored for HHV-6B infection who underwent brain MRI before and after transplantation. Volumetric analysis of the hippocampus was performed. Of the 107 patients that received HSCT at Nagoya University Hospital Between July 2008 and April 2014, 20 were eligible for volumetric analysis. Eight patients had HHV-6B infection, of whom two had encephalopathy at the time of HHV-6B infection. None of the 12 patients without HHV-6B infection had encephalopathy. The median ratio of the right hippocampal volume from before to after transplantation was 0.93 in patients with HHV-6B infection and 1.02 in without HHV-6B infection (

Indexed as

childrenhematopoietic stem cell transplanthippocampushuman herpesvirus 6B

Identifiers

PMID33917715
PMCPMC8068176
OpenAlexW3144529215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.