Evidence map›Paper›PMID 33917636›Full record

ArticleMolecules (Basel, Switzerland)2021

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids.

Sophie Hoenke, Martin A Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, René Csuk

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sophie HoenkeOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
Martin A ChristophOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
Sander FriedrichOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
Niels HeiseOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0002-6540-6357
Benjamin BrandesOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0002-0473-8489
Hans-Peter DeignerInstitute of Precision Medicine, Medical and Life Science Faculty, Furtwangen University, Jakob-Kienzle-Str. 17, D-78054 Villigen-Schwenningen, Germany.
Ahmed Al-HarrasiChair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Birkat Al-Mauz, PC 616 Nizwa, Oman.ORCID 0000-0002-0815-5942
René CsukOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0001-7911-290X
Martin Luther University Halle-Wittenberg · DEFurtwangen University · DEUniversity of Nizwa · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides

Indexed as

AmidesAnimalsCell DeathCell Line, TumorCyclohexylaminesHumansInhibitory Concentration 50MiceNIH 3T3 CellsPentacyclic Triterpenes1,4-diaminocyclohexaneAmidesCyclohexylaminesPentacyclic Triterpenes1,4-cyclohexyldiaminesbetulinic acidcytotoxicityoleanolic acidplatanic acidursolic acid

Identifiers

PMID33917636
PMCPMC8038856
OpenAlexW3150296603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.