Evidence map›Paper›PMID 33917595›Full record

ArticleInternational journal of molecular sciences2021

Towards the Enhancement of Essential Oil Components' Antimicrobial Activity Using New Zein Protein-Gated Mesoporous Silica Microdevices.

Elisa Poyatos-Racionero, Gemma Guarí-Borràs, María Ruiz-Rico, Ángela Morellá-Aucejo, Elena Aznar, José Manuel Barat, Ramón Martínez-Máñez, María Dolores Marcos, Andrea Bernardos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Recent Advances in Nanoparticle-Mediated Antibacterial Photodynamic Therapy.International journal of molecular sciences · 2025
    Review
  2. Chemical characterization and encapsulation ofFrontiers in pharmacology · 2025
    Article
  3. Article
  4. Nanomaterials (Basel, Switzerland) · 2022
    Article
  5. Encapsulation ofMolecules (Basel, Switzerland) · 2022
    Article
  6. The Physical Chemistry and Chemical Physics (PCCP) Section of theInternational journal of molecular sciences · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elisa Poyatos-RacioneroInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0001-8294-5945
Gemma Guarí-BorràsInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0002-8845-6277
María Ruiz-RicoDepartamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0002-7333-1236
Ángela Morellá-AucejoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.
Elena AznarInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0003-0361-3876
José Manuel BaratDepartamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0001-8487-7114
Ramón Martínez-MáñezInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0001-5873-9674
María Dolores MarcosInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.
Andrea BernardosInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València and Universitat de València, Camino de Vera s/n, 46022 Valencia, Spain.ORCID 0000-0002-3842-5771

Funding

Generalitat Valenciana PROMETEO 2018/024Ministerio de Ciencia, Innovación y Universidades RTI2018-100910-B-C41Ministerio de Ciencia, Innovación y Universidades RTI2018-101599-B-C21-ARMinisterio de Ciencia, Innovación y Universidades RTI2018-101599-B-C22-AR
6 · The paper itself

Abstract

The development of new food preservatives is essential to prevent foodborne outbreaks or food spoilage due to microbial growth, enzymatic activity or oxidation. Furthermore, new compounds that substitute the commonly used synthetic food preservatives are needed to stifle the rising problem of microbial resistance. In this scenario, we report herein, as far as we know, for the first time the use of the zein protein as a gating moiety and its application for the controlled release of essential oil components (EOCs). The design of microdevices consist of mesoporous silica particles loaded with essential oils components (thymol, carvacrol and cinnamaldehyde) and functionalized with the zein (prolamin) protein found in corn as a molecular gate. The zein protein grafted on the synthesized microdevices is degraded by the proteolytic action of bacterial enzymatic secretions with the consequent release of the loaded essential oil components efficiently inhibiting bacterial growth. The results allow us to conclude that the new microdevice presented here loaded with the essential oil component cinnamaldehyde improved the antimicrobial properties of the free compound by decreasing volatility and increasing local concentration.

Indexed as

Anti-Bacterial AgentsOils, VolatilePorositySilicon DioxideZeinAnti-Bacterial AgentsOils, VolatileSilicon DioxideZeincinnamaldehydecornE. coliessential oil componentsfoodborne illnessesfood preservativemesoporous silica particlesmolecular gateprotease secretionzein

Identifiers

PMID33917595
PMCPMC8038806

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.