ArticleAnimals : an open access journal from MDPI2021
Changes in the Relationship between Ionized and Total Calcium in Clinically Healthy Dairy Cows in the Period around Calving.
Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Discriminatory performance of total calcium for ionized hypocalcemia and factors affecting ionized calcium in Assaf ewes during the pre- and post-lambing periods.Journal of veterinary internal medicine · 2026Article
- Hypocalcemia in Dairy Cows: A Systematic Review of Metabolic Implications and Management Strategies.Life (Basel, Switzerland) · 2026Review
- Reticuloruminal Motility Monitoring for the Prediction of Peripartal Hypocalcemia in Cattle.Animals : an open access journal from MDPI · 2025Article
- Effects of a Phosphorus-Binding Feed Supplement on the Blood P and Ca Levels in Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- Effects of feeding a negative dietary cation and anion difference diet to twin-bearing Merino ewes in late gestation on parturition outcomes.Journal of animal science · 2024Article
- Preoperative and Surgical Predictors of the Treatment Outcome of Dairy Cows with Right Abomasal Displacement-A Retrospective Study of 234 Cases.Animals : an open access journal from MDPI · 2023Article
- Plasma ionized calcium and magnesium concentrations and prevalence of subclinical hypocalcemia and hypomagnesemia in postpartum grazing Holstein cows from southern Chile.Veterinary and animal science · 2023Article
- Noninvasive measurement of blood calcium concentration using electrocardiography in peripartum Jersey cows.Frontiers in veterinary science · 2023Article
- Predictors of blood ionized calcium concentration in sick adult cattle.Journal of veterinary internal medicineArticle
- Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving.Journal of veterinary internal medicineArticle
- Evaluation of the relationship between ionized and total calcium concentrations in blood during the first week of lactation in dairy cows.Journal of veterinary internal medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We aimed to establish a model for prediction of iCa from tCa, using multivariable regressions with diverse blood constituents. Blood was taken from 14 cows at days -2, 0, 2, 4, 7, and 14 relative to parturition. Cows were clinically healthy, and no hypocalcaemia prophylaxis and treatment were applied. Total calcium and further parameters were determined from frozen serum. Ionized calcium, blood gases, and electrolytes were determined from heparin-stabilized blood samples. Linear regression between iCa and tCa was estimated. Precision improved only slightly using a multivariable model. Best precision was achieved when estimating the iCa:tCa ratio from other blood constituents. To identify the reason behind the poorly predictive value of tCa for iCa, the relative changes of iCa and tCa around calving were calibrated to the respective values of day -2 (=100%) for each cow. An increase in the iCa:tCa ratio was observed from 0.43 at day -2 to 0.48 at day 0, followed by a gradual decrease towards 0.43 at day 7. We conclude that routine measurement of iCa should be implemented in the diagnosis of hypocalcaemia. An optimized estimate of iCa from tCa with non-esterified fatty acids (NEFA), beta-hydroxybutyric acid, cholesterol, and phosphorous as co-predictors is still poorly satisfying.
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