Evidence map›Paper›PMID 33917480›Full record

ArticleCancers2021

Effects of Epstein-Barr Virus Infection on the Risk and Prognosis of Primary Laryngeal Squamous Cell Carcinoma: A Hospital-Based Case-Control Study in Taiwan.

Li-Ang Lee, Tuan-Jen Fang, Hsueh-Yu Li, Hai-Hua Chuang, Chung-Jan Kang, Kai-Ping Chang, Chun-Ta Liao, Tse-Ching Chen, Chung-Guei Huang, Tzu-Chen Yen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. LaryngealMicroorganisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Li-Ang LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.ORCID 0000-0001-8414-595X
Tuan-Jen FangDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.ORCID 0000-0002-7805-3458
Hsueh-Yu LiDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
Hai-Hua ChuangFaculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
Chung-Jan KangDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
Kai-Ping ChangDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
Chun-Ta LiaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
Tse-Ching ChenFaculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
Chung-Guei HuangDepartment of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan City 33305, Taiwan.
Tzu-Chen YenFaculty of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
Chang Gung University · TWNational Taipei University of Technology · TW

Funding

Chang Gung Medical Foundation 3C0661, 3C0662, 3C0663, and 3F1092
6 · The paper itself

Abstract

Mounting molecular evidence supports Epstein-Barr virus (EBV) involvement in the pathogenesis of laryngeal squamous cell carcinoma (LSCC); however, the epidemiological data are inconsistent. In this retrospective case-control study, we aimed to determine whether EBV infection underlies the risk and prognosis of LSCC. The prevalence of EBV infection, as analyzed using an EBV DNA polymerase chain reaction assay, was significantly higher in 42 Taiwanese patients with newly diagnosed primary LSCC, compared to 39 age- and sex-matched control patients without cancer (48% vs. 19%). Furthermore, most of the

Indexed as

B2MBCL-2CD161CD3disease-free survivalEBEREpstein–Barr viruslaryngeal squamous cell carcinomalocal recurrencerisk

Identifiers

PMID33917480
PMCPMC8038767
OpenAlexW3141956290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.