Evidence map›Paper›PMID 33917250›Full record

ArticleInternational journal of molecular sciences2021

Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton's Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease.

Fani Ziouti, Maximilian Rummler, Beatrice Steyn, Tobias Thiele, Anne Seliger, Georg N Duda, Bjarne Bogen, Bettina M Willie, Franziska Jundt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Mechanobiology of Bone Metastatic Cancer.Current osteoporosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Fani ZioutiDepartment of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany.
Maximilian RummlerResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.ORCID 0000-0002-0788-7172
Beatrice SteynResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.
Tobias ThieleJulius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Anne SeligerJulius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Georg N DudaJulius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Bjarne BogenInstitute of Clinical Medicine, University of Oslo and Department of Immunology, Oslo University Hospital, 0424 Oslo, Norway.
Bettina M WillieResearch Centre, Shriners Hospital for Children-Canada, Montreal, QC H4A 0A9, Canada.
Franziska JundtDepartment of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-8661-7110
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DEShriners Hospitals for Children - Canada · CAComprehensive Cancer Center Mainfranken · DEOslo University Hospital · NOUniversitätsklinikum Würzburg · DE

Funding

Celgene GRANT-DEU-038Deutsche Forschungsgemeinschaft JU 426/5-1
6 · The paper itself

Abstract

Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton's tyrosine kinase inhibitor CC-292 (spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microcomputed tomography (microCT) and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD.

Indexed as

Stress, MechanicalAcrylamidesAgammaglobulinaemia Tyrosine KinaseAnimalsBone DiseasesDisease Models, AnimalHumansMiceMultiple MyelomaOsteolysisProtein Kinase InhibitorsPyrimidinesX-Ray MicrotomographyAcrylamidesAgammaglobulinaemia Tyrosine KinaseBTK protein, humanProtein Kinase InhibitorsPyrimidinesspebrutinibbone adaptationBruton’s tyrosine kinase inhibitor CC-292cancer-induced bone diseasemechanical loadingmultiple myelomaskeletal mechanobiology

Identifiers

PMID33917250
PMCPMC8067978
OpenAlexW3146113670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.