Evidence map›Paper›PMID 33917224›Full record

ArticleMetabolites2021

Bilal Moiz, Jonathan Garcia, Sarah Basehore, Angela Sun, Andrew Li, Surya Padmanabhan, Kaitlyn Albus, Cholsoon Jang, Ganesh Sriram, Alisa Morss Clyne

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Excess glutamine rewires endothelial cell metabolism.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
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  5. Article
  6. Metabolic engineering communications · 2024
    Article
  7. Article
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bilal MoizFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Jonathan GarciaSchool of Bioengineering, Science, and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
Sarah BasehoreSchool of Bioengineering, Science, and Heath Systems, Drexel University, Philadelphia, PA 19104, USA.
Angela SunFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Andrew LiFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Surya PadmanabhanFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Kaitlyn AlbusFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Cholsoon JangDepartment of Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA 92697, USA.
Ganesh SriramDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA.
Alisa Morss ClyneFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.ORCID 0000-0003-2462-2122
University of Maryland, College Park · USDrexel University · USUniversity of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
The effect of laminar and disturbed flow on endothelial glucose metabolismR01HL140239 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI MORSS CLYNE, ALISA S · 2018 to 2022
$1.9M
National Science Foundation DGE-1632976NCI NIH HHS P30 CA062203NHLBI NIH HHS R01 HL140239NIH HHS 1R01HL140239
6 · The paper itself

Abstract

Disrupted endothelial metabolism is linked to endothelial dysfunction and cardiovascular disease. Targeted metabolic inhibitors are potential therapeutics; however, their systemic impact on endothelial metabolism remains unknown. In this study, we combined stable isotope labeling with

Indexed as

aldose reductase inhibitorscardiovascular diseaseendothelial metabolismfluxomicshexosamine biosynthetic pathwaymetabolic flux analysispentose phosphate pathwaypolyol pathway

Identifiers

PMID33917224
PMCPMC8068087
OpenAlexW3151126007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.