ArticleJournal of clinical medicine2021
Severity and Duration of Acute Kidney Injury and Chronic Kidney Disease after Cardiac Surgery.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Pooled it
- Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.Circulation · 2024Trial
- A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery.Intensive care medicine · 2026Article
- Preoperative Urine Albumin-to-Creatinine Ratio Predicts Acute Kidney Injury After Coronary Artery Bypass Grafting.Saudi medical journal · 2026Article
- Integrating Bulk and Single-Cell RNA Sequencing Identifies and Validates Lactylation-Related Signatures in Acute Kidney Injury.Biomedicines · 2026Article
- Multiple metabolic analysis of [Heliyon · 2025Article
- Infected necrotizing pancreatitis: clinical features, microbial patterns, and outcomes in a Saudi tertiary center.Frontiers in cellular and infection microbiology · 2025Article
- A Mild Increase in Serum Creatinine after Surgery Is Associated with Increased Mortality.Journal of clinical medicine · 2024Article
- Predicting pediatric cardiac surgery-associated acute kidney injury using machine learning.Pediatric nephrology (Berlin, Germany) · 2024Article
- Acute Kidney Injury Duration and 20-Year Risks of CKD and Cardiovascular Disease.Kidney international reports · 2024Article
- Adverse renal effects associated with cardiopulmonary bypass.Perfusion · 2024Review
- A pilot study to explore patterns and predictors of delayed kidney decline after cardiopulmonary bypass.Scientific reports · 2024Article
- Nephrology intervention to avoid acute kidney injury in patients awaiting cardiac surgery: randomized clinical trial.Frontiers in nephrology · 2024Article
- Impact of Postarrest Vasoactive-Inotropic Score on Acute Kidney Injury in Cardiac Arrest Survivors: A Retrospective Cohort Study.Reviews in cardiovascular medicine · 2024Article
- A Signature of Pre-Operative Biomarkers of Cellular Senescence to Predict Risk of Cardiac and Kidney Adverse Events after Cardiac Surgery.Cardiology and cardiovascular medicine · 2024Article
- Article
- Cardiac Surgery-Associated Acute Kidney Injury: Current Updates and Perspectives.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to evaluate whether the duration and stage of acute kidney injury (AKI) are associated with the occurrence of chronic kidney disease (CKD) in patients undergoing cardiac or thoracic aortic surgery. A total of 2009 cases were reviewed. The patients with postoperative AKI stage 1 and higher stage were divided into transient (serum creatinine elevation ≤48 h) or persistent (>48 h) AKI, respectively. Estimated glomerular filtration rate (eGFR) values during three years after surgery were collected. Occurrence of new-onset CKD stage 3 or higher or all-cause mortality was determined as the primary outcome. Multivariable Cox regression and Kaplan-Meier survival analysis were performed. The Median follow-up of renal function after surgery was 32 months. The cumulative incidences of our primary outcome at one, two, and three years after surgery were 19.8, 23.7, and 26.1%. There was a graded significant association of AKI with new-onset CKD during three years after surgery, except for transient stage 1 AKI (persistent stage 1: HR 3.11, 95% CI 2.62-4.91; transient higher stage: HR 4.07, 95% CI 2.98-6.11; persistent higher stage: HR 13.36, 95% CI 8.22-18.72). There was a significant difference in survival between transient and persistent AKI at the same stage. During three years after cardiac surgery, there was a significant and graded association between AKI stages and the development of new-onset CKD, except for transient stage 1 AKI. This association was stronger when AKI lasted more than 48 h at the same stage. Both duration and severity of AKI provide prognostic value to predict the development of CKD.
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Registered trials
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