Evidence map›Paper›PMID 33917200›Full record

ArticleInternational journal of molecular sciences2021

Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells.

Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnatova and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Investigating Amphoteric 3,4'-Biscoumarin-BasedInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Monika HudáčováDepartment of Biochemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0003-3816-1654
Slávka HamuľakováDepartment of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, Pavol Jozef Šafárik University in Košice, Moyzesova 11, 040 01 Kosice, Slovakia.ORCID 0000-0002-9081-3720
Eva KonkoľováDepartment of Biochemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0003-0285-3843
Rastislav JendželovskýDepartment of Cellular Biology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0001-6338-0723
Jana VargováDepartment of Cellular Biology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0002-4066-3453
Juraj ŠevcDepartment of Cellular Biology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0001-8050-4185
Peter FedoročkoDepartment of Cellular Biology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0002-1138-6282
Ondrej SoukupDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-6376-8701
Jana JanočkováBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Veronika IhnatovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Tomáš KučeraDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-6650-1738
Petr BzonekDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-9651-7917
Nikola NovakovaBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
Daniel JunDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-0882-6304
Lucie JunovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.
Jan KorábečnýDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-6977-7596
Kamil KučaBiomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Mária KožurkováDepartment of Biochemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia.ORCID 0000-0002-8344-0671
University of Pavol Jozef Šafárik · SKUniversity Hospital Hradec Králové · CZUniversity of Defence · CZNational Institute of Mental Health · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel C4-C7-tethered biscoumarin derivatives (

Indexed as

Chemistry Techniques, SyntheticModels, MolecularA549 CellsAlzheimer DiseaseAntineoplastic AgentsBlood-Brain BarrierCell CycleCell SurvivalCholinesterase InhibitorsCoumarinsDose-Response Relationship, DrugEnzyme ActivationHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsCholinesterase InhibitorsCoumarinsA549Alzheimer’s diseaseantiproliferative activitybiscoumarinblood–brain barriercholinesterase

Identifiers

PMID33917200
PMCPMC8068036
OpenAlexW3149172361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.