Evidence map›Paper›PMID 33917165›Full record

Trial reportNutrients2021

A Dietary Intervention High in Green Leafy Vegetables Reduces Oxidative DNA Damage in Adults at Increased Risk of Colorectal Cancer: Biological Outcomes of the Randomized Controlled Meat and Three Greens (M3G) Feasibility Trial.

Andrew D Frugé, Kristen S Smith, Aaron J Riviere, Rachel Tenpenny-Chigas, Wendy Demark-Wahnefried, Anna E Arthur, William M Murrah, William J van der Pol, Shanese L Jasper, Casey D Morrow and 2 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
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  10. Article
  11. Article
  12. Article
  13. Therapeutic approaches to colorectal cancerFrontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Andrew D FrugéDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0001-9119-1380
Kristen S SmithDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-8845-0609
Aaron J RiviereDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-1063-6494
Rachel Tenpenny-ChigasDepartment of Nutrition, Dietetics and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Anna E ArthurDepartment of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA.ORCID 0000-0002-5208-4336
William M MurrahDepartment of Educational Foundations, Leadership, and Technology, Auburn University, Auburn, AL 36849, USA.
William J van der PolDepartment of Computational Biology and Bioinformatics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Shanese L JasperDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Casey D MorrowDepartment of Drug Discovery and Development, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USA.
Robert D ArnoldDepartment of Drug Discovery and Development, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USA.ORCID 0000-0001-6143-3991
Kimberly Braxton-LloydDepartment of Pharmacy Services, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USA.
Auburn University · USUniversity of Alabama at Birmingham · USUniversity of Illinois Urbana-Champaign · US

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
Cancer Prevention & Control Training ProgramR25CA047888 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY, MENESES, KAREN M · 1988 to 2016
$11.2M
NCI NIH HHS R25 CA047888NCI NIH HHS R25CA047888NIDDK NIH HHS P30 DK056336NIH HHS UL1TR003096
6 · The paper itself

Abstract

Green leafy vegetables (GLV) may reduce the risk of red meat (RM)-induced colonic DNA damage and colorectal cancer (CRC). We previously reported the primary outcomes (feasibility) of a 12-week randomized controlled crossover trial in adults with habitual high RM and low GLV intake with body mass index (BMI) > 30 kg/m

Indexed as

Oxidative StressVegetablesAdultBiodiversityBiomarkersColorectal NeoplasmsCross-Over StudiesFeasibility StudiesFecesHumansMiddle AgedPhylogenyBiomarkers8-hydroxy-2′deoxyguanosinechemopreventioncolorectal cancerdietgreen leafy vegetablesred meat

Identifiers

PMID33917165
PMCPMC8067874
OpenAlexW3145459359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.