Evidence map›Paper›PMID 33917126›Full record

ArticleInternational journal of molecular sciences2021

The

Tiziana Bachetti, Francesca Rosamilia, Martina Bartolucci, Giuseppe Santamaria, Manuela Mosconi, Serenella Sartori, Maria Rosaria De Filippo, Marco Di Duca, Valentina Obino, Stefano Avanzini and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Human germline biallelic loss-of-functionJournal of human immunity · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Tiziana BachettiLaboratory of Developmental Neurobiology, Dipartimento di Scienze della Terra dell'Ambiente e della Vita (DISTAV), Università di Genova, Viale Benedetto XV, 5, 16132 Genova, Italy.
Francesca RosamiliaHealth Science Department (DISSAL), Biostatistics Unit, Università di Genova, Via Pastore 1, 16132 Genova, Italy.ORCID 0000-0003-4979-9397
Martina BartolucciCore Facilities-Clinical Proteomics and Metabolomics, IRCCS, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.ORCID 0000-0001-5289-4219
Giuseppe SantamariaUOSD Laboratorio di Genetica e Genomica delle Malattie Rare, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, 16148 Genova, Italy.
Manuela MosconiFetal and Perinatal Pathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Serenella SartoriCOSR-Center for Omics Sciences, IRCCS Hospital San Raffaele, Dibit2-Basilica, 3A3, Via Olgettina 58, 20132 Milano, Italy.
Maria Rosaria De FilippoCOSR-Center for Omics Sciences, IRCCS Hospital San Raffaele, Dibit2-Basilica, 3A3, Via Olgettina 58, 20132 Milano, Italy.
Marco Di DucaLaboratorio di Fisiopatologia dell' Uremia, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Valentina ObinoLaboratory of Developmental Neurobiology, Dipartimento di Scienze della Terra dell'Ambiente e della Vita (DISTAV), Università di Genova, Viale Benedetto XV, 5, 16132 Genova, Italy.
Stefano AvanziniPediatric Surgery Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Domenico MavilioDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, Via Manzoni 113, 20089 Milan, Italy.
Simona CandianiLaboratory of Developmental Neurobiology, Dipartimento di Scienze della Terra dell'Ambiente e della Vita (DISTAV), Università di Genova, Viale Benedetto XV, 5, 16132 Genova, Italy.ORCID 0000-0002-4453-5475
Andrea PetrettoCore Facilities-Clinical Proteomics and Metabolomics, IRCCS, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Alessio Pini PratoCentro Bosio per la Patologia Digestiva Pediatrica, Ospedale Infantile AON SS Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Isabella CeccheriniUOSD Laboratorio di Genetica e Genomica delle Malattie Rare, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, 16148 Genova, Italy.
Francesca LantieriHealth Science Department (DISSAL), Biostatistics Unit, Università di Genova, Via Pastore 1, 16132 Genova, Italy.ORCID 0000-0002-8923-0165
Istituto Giannina Gaslini · ITUniversity of Genoa · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITUniversity of Milan · IT

Funding

Ministero della Salute GR-2011-02347381
6 · The paper itself

Abstract

Hirschsprung (HSCR) Associated Enterocolitis (HAEC) is a common life-threatening complication in HSCR. HAEC is suggested to be due to a loss of gut homeostasis caused by impairment of immune system, barrier defense, and microbiome, likely related to genetic causes. No gene has been claimed to contribute to HAEC occurrence, yet. Genetic investigation of HAEC by Whole-Exome Sequencing (WES) on 24 HSCR patients affected (HAEC) or not affected (HSCR-only) by enterocolitis and replication of results on a larger panel of patients allowed the identification of the HAEC susceptibility variant p.H187Q in the Oncostatin-M receptor (

Indexed as

Disease SusceptibilitySignal TransductionAllelesEnterocolitisExome SequencingGene ExpressionGene FrequencyGenetic VariationGenotypeHirschsprung DiseaseHumansModels, MolecularOncostatin M Receptor beta SubunitProtein ConformationProteomicsStructure-Activity RelationshipOncostatin M Receptor beta SubunitOSMR protein, humangut inflammationHirschsprung Associated Enterocolitis (HAEC)mucosal immunityOncostatin-M receptor (OSMR)proteomicsWhole-Exome Sequencing (WES)

Identifiers

PMID33917126
PMCPMC8067804
OpenAlexW3155978104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.