Evidence map›Paper›PMID 33917124›Full record

ArticleInternational journal of molecular sciences2021

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation.

Laura Nicolle, Jens Casper, Melanie Willimann, Céline M A Journot, Pascal Detampel, Tomaž Einfalt, Hiu Man Grisch-Chan, Beat Thöny, Sandrine Gerber-Lemaire, Jörg Huwyler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura NicolleGroup for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC SCI-SB-SG, Station 6, CH-1015 Lausanne, Switzerland.
Jens CasperDivision of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.ORCID 0000-0002-0504-0461
Melanie WillimannDivision of Metabolism and Children's Research Center, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland.
Céline M A JournotGroup for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC SCI-SB-SG, Station 6, CH-1015 Lausanne, Switzerland.
Pascal DetampelDivision of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.ORCID 0000-0002-2210-5220
Tomaž EinfaltDivision of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
Hiu Man Grisch-ChanDivision of Metabolism and Children's Research Center, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland.ORCID 0000-0002-5343-2013
Beat ThönyDivision of Metabolism and Children's Research Center, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland.
Sandrine Gerber-LemaireGroup for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC SCI-SB-SG, Station 6, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-6519-2782
Jörg HuwylerDivision of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.ORCID 0000-0003-1748-5676

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung CRSII5_180257
6 · The paper itself

Abstract

There is an increasing interest in cationic polymers as important constituents of non-viral gene delivery vectors. In the present study, we developed a versatile synthetic route for the production of covalent polymeric conjugates consisting of water-soluble depolymerized chitosan (dCS; M

Indexed as

Gene Transfer TechniquesTransfectionAnimalsCell Line, TumorCell SurvivalChemical PhenomenaChemistry Techniques, SyntheticChitosanColloidsDNAGene ExpressionGenes, ReporterGenetic VectorsHumansMagnetic Resonance SpectroscopyMiceChitosanColloidsDNAPolyethyleneiminechitosanDNA condensationgene delivery vectorpolyethylenimine copolymer

Identifiers

PMID33917124
PMCPMC8067803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.