Evidence map›Paper›PMID 33917118›Full record

ArticlePharmaceutics2021

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products.

Isabel Gonzalez-Alvarez, Marival Bermejo, Yasuhiro Tsume, Alejandro Ruiz-Picazo, Marta Gonzalez-Alvarez, Bart Hens, Alfredo Garcia-Arieta, Greg E Amidon, Gordon L Amidon

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Isabel Gonzalez-AlvarezDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1685-142X
Marival BermejoDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5022-0544
Yasuhiro TsumeDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Alejandro Ruiz-PicazoDepartment Engineering Pharmacy Section, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, Spain.
Marta Gonzalez-AlvarezDepartment Engineering Pharmacy Section, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, Spain.ORCID 0000-0002-8122-1504
Bart HensDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4229-9843
Alfredo Garcia-ArietaDivisión de Farmacología y Evaluación Clínica, Departamento de Medicamentos de Uso Humano, Agencia Española de Medicamentos y Productos Sanitarios, 28022 Madrid, Spain.ORCID 0000-0002-9702-6973
Greg E AmidonDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Gordon L AmidonDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Universitat de Miguel Hernández d'Elx · ESUniversity of Michigan · USAgencia Española de Medicamentos y Productos Sanitarios · ES

Funding

Enhanced Oral Delivery of Low Solubility Drugs using Cocrystal Design - equipment supplementR01GM107146 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODRIGUEZ-HORNEDO, NAIR · 2015 to 2018
$1.3M
Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2016-78756NIGMS NIH HHS Award # RGM107146U.S. Food and Drug Administration HHSF223201310144CU.S. Food and Drug Administration HHSF223201510157C
6 · The paper itself

Abstract

The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (

Indexed as

BCS class IIdissolution modellinggastrointestinal simulatorin vitro dissolutionweak base

Identifiers

PMID33917118
PMCPMC8067797
OpenAlexW3143116882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.