Evidence map›Paper›PMID 33917086›Full record

ArticleInternational journal of molecular sciences2021

The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI).

Lisa Elefanti, Carolina Zamuner, Paolo Del Fiore, Camilla Stagni, Stefania Pellegrini, Luigi Dall'Olmo, Alessio Fabozzi, Rebecca Senetta, Simone Ribero, Roberto Salmaso and 8 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Association BetweenDiseases (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Review
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  9. Subungual Melanoma: A Single Institution Experience.Medical sciences (Basel, Switzerland) · 2021
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Lisa ElefantiImmunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Carolina ZamunerAnatomy and Histology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Paolo Del FioreSoft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-2862-8014
Camilla StagniDepartment of Molecular Medicine, University of Padua, 35128 Padua, Italy.
Stefania PellegriniImmunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0001-5198-5901
Luigi Dall'OlmoSoft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Alessio FabozziOncology Unit 3, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Rebecca SenettaPathology Unit, Department of Oncology, University of Turin, 10124 Turin, Italy.
Simone RiberoSection of Dermatology, Department of Medical Sciences, University of Turin, 10124 Turin, Italy.
Roberto SalmasoPathological Anatomy Unit, Padua University Hospital, 35128 Padua, Italy.
Simone MocellinSoft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Franco BassettoPlastic Surgery Unit, Padua University Hospital, 35128 Padua, Italy.
Francesco CavallinIndependent Statistician, 36020 Solagna, Italy.ORCID 0000-0002-0831-3971
Anna Lisa TosiPathological Anatomy Unit, AULSS5, Santa Maria della Misericordia Hospital, 45100 Rovigo, Italy.ORCID 0000-0002-2790-2747
Francesca GaluppiniSurgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35128 Padua, Italy.
Angelo Paolo Dei TosPathological Anatomy Unit, Padua University Hospital, 35128 Padua, Italy.
Chiara MeninImmunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-8907-772X
Rocco CappellessoPathological Anatomy Unit, Padua University Hospital, 35128 Padua, Italy.ORCID 0000-0002-0480-3412
Istituto Oncologico Veneto · ITUniversity of Padua · ITUniversity of Turin · ITIstituto Nazionale di Statistica · ITOspedale Santa Maria della Misericordia di Rovigo · IT

Funding

Istituto Oncologico Veneto BIGID219MENI
6 · The paper itself

Abstract

Acral melanoma (AM) is a rare and aggressive subtype of melanoma affecting the palms, soles, and nail apparatus with similar incidence among different ethnicities. AM is unrelated to ultraviolet radiation and has a low mutation burden but frequent chromosomal rearrangements and gene amplifications. Next generation sequencing of 33 genes and somatic copy number variation (CNV) analysis with genome-wide single nucleotide polymorphism arrays were performed in order to molecularly characterize 48 primary AMs of Italian patients in association with clinicopathological and prognostic features.

Indexed as

Biomarkers, TumorDisease SusceptibilityAgedAged, 80 and overCutaneous Malignant MelanomaDNA Copy Number VariationsFemaleHumansItalyMaleMelanomaMiddle AgedMutationNeoplasm GradingNeoplasm StagingPolymorphism, Single NucleotideBiomarkers, Tumoracral melanomaARID1ABRAFcopy number variationsKITNRASPREX2TERT promoterTP53

Identifiers

PMID33917086
PMCPMC8067752
OpenAlexW3155684779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.