Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach.

Md Ishak Khan, Fuad Hasan, Khandakar Abu Hasan Al Mahmud, Ashfaq Adnan

Abstract read

In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

From Axonal Growth to Neurodegeneration: The Dual Role of Neurofilament Dynamics in Health and Disease.NeuroSci · 2026
Review
Viscoelastic damage evaluation of the axon.Frontiers in bioengineering and biotechnology · 2022
Article
Shock-Induced Damage Mechanism of Perineuronal Nets.Biomolecules · 2021
Article
Effect of Strain Rate on Single Tau, Dimerized Tau and Tau-Microtubule Interface: A Molecular Dynamics Simulation Study.Biomolecules · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Md Ishak KhanDepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0001-7680-9613

Fuad HasanDepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0003-1889-4877

Khandakar Abu Hasan Al MahmudDepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.

Ashfaq AdnanDepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.

Funding

Office of Naval Research N00014-18-1-2082

6 · The paper itself

Abstract

Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments (NF). This study performs molecular dynamics (MD) simulations on NFs to extract their strain rate-dependent behavior. It is found that they are highly stretchable and show multiple stages of unfolding. Furthermore, NFs show high tensile stiffness. Also, viscoelastic modeling shows that they correspond to simplified viscoelastic models. This study effectively enhances the existent axonal models focusing on axonal injury.

Indexed as

Molecular Dynamics SimulationCytoskeletonIntermediate Filamentstau ProteinsTensile Strengthtau Proteinsaxonal cytoskeletonaxonal injurymechanical behaviorneurofilamentsviscoelastic modeling

Identifiers

PMID33917073

DOI10.3390/biom11040540

PMCPMC8067762

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.