Evidence map›Paper›PMID 33916814›Full record

ArticleMolecules (Basel, Switzerland)2021

Nanoparticle-Based Rifampicin Delivery System Development.

Marjan Motiei, Luis Pleno de Gouveia, Tomáš Šopík, Robert Vícha, David Škoda, Jaroslav Císař, Reza Khalili, Eva Domincová Bergerová, Lukáš Münster, Haojie Fei and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Marjan MotieiCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Luis Pleno de GouveiaiMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 169-003 Lisbon, Portugal.ORCID 0000-0001-5611-0047
Tomáš ŠopíkCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.ORCID 0000-0001-5671-1889
Robert VíchaDepartment of Chemistry, Faculty of Technology, TBU, Vavrečkova 275, 76001 Zlín, Czech Republic.ORCID 0000-0002-5229-9863
David ŠkodaCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.ORCID 0000-0002-3787-1956
Jaroslav CísařCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Reza KhaliliDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455/2, 12808 Prague 2, Czech Republic.
Eva Domincová BergerováCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Lukáš MünsterCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Haojie FeiCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Vladimír SedlaříkCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Petr SáhaCentre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Tomas Bata University in Zlín · CZCharles University · CZUniversity of Lisbon · PT

Funding

Ministry of Education, Youth and Sport of the Czech Republik- DKRVO RP/CPS/2020/005
6 · The paper itself

Abstract

The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs, is required. Herein, two innovative polyelectrolyte nanoparticles (PENs), composed of an amphiphilic chitosan core and a polycationic shell, were synthesized at alkaline pH, and in vitro performances were assessed by

Indexed as

Drug Delivery SystemsCalorimetry, Differential ScanningChromatography, High Pressure LiquidDextran SulfateDrug LiberationHydrogen-Ion ConcentrationNanoparticlesParticle SizePolyelectrolytesProton Magnetic Resonance SpectroscopyRifampinSpectrophotometry, UltravioletSpectroscopy, Fourier Transform InfraredStatic ElectricityX-Ray DiffractionDextran SulfatePolyelectrolytesRifampinalkaline pHascorbic acidpolyelectrolyte nanoparticlesrifampicin

Identifiers

PMID33916814
PMCPMC8038351
OpenAlexW3152404058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.