Evidence map›Paper›PMID 33916775›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Repurposing Avermectins and Milbemycins against

Lara Muñoz-Muñoz, Carolyn Shoen, Gaye Sweet, Asunción Vitoria, Tim J Bull, Michael Cynamon, Charles J Thompson, Santiago Ramón-García

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Identification ofFrontiers in microbiology · 2025
    Article
  2. Article
  3. Article
  4. Repurposing β-Lactams for the Treatment ofAntibiotics (Basel, Switzerland) · 2023
    Article
  5. Ivermectin Attenuates CClInternational journal of molecular sciences · 2022
    Article
  6. Review
  7. Review
  8. The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of theInternational journal of molecular sciences · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Lara Muñoz-MuñozDepartment of Microbiology, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
Carolyn ShoenState University of New York Upstate Medical Center, Syracuse, NY 13210, USA.
Gaye SweetDepartment of Microbiology and Immunology, Centre for Tuberculosis Research, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Asunción VitoriaDepartment of Microbiology, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.
Tim J BullInstitute for Infection & Immunity, St. George's University of London, London SW17 0RE, UK.ORCID 0000-0001-8082-6811
Michael CynamonState University of New York Upstate Medical Center, Syracuse, NY 13210, USA.
Charles J ThompsonDepartment of Microbiology and Immunology, Centre for Tuberculosis Research, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Santiago Ramón-GarcíaDepartment of Microbiology, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0002-8480-0325
Universidad de Zaragoza · ESSUNY Upstate Medical University · USUniversity of British Columbia · CASt George's, University of London · GB

Funding

CIHR MOP-82855European Society of Clinical Microbiology and Infectious Diseases ESCMID Research GrantsGovernment of Aragon LMP132_18 and Pre-doctoral Fellowship
6 · The paper itself

Abstract

Infections caused by nontuberculous mycobacteria (NTM) are increasing worldwide, resulting in a new global health concern. NTM treatment is complex and requires combinations of several drugs for lengthy periods. In spite of this, NTM disease is often associated with poor treatment outcomes. The anti-parasitic family of macrocyclic lactones (ML) (divided in two subfamilies: avermectins and milbemycins) was previously described as having activity against mycobacteria, including

Indexed as

avermectinsmilbemycin oximeMycobacteroides abscessusnontuberculous mycobacteriarepurposingselamectin

Identifiers

PMID33916775
PMCPMC8066277
OpenAlexW3141867322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.