Evidence map›Paper›PMID 33916750›Full record

ArticleJournal of clinical medicine2021

The Role of Soluble Low-Density Lipoprotein Receptor-Related Protein-1 in Obstructive Sleep Apnoea.

Martina Meszaros, Laszlo Kunos, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Zsofia Lazar, Andras Bikov

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Martina MeszarosDepartment of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.
Laszlo KunosDepartment of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.
Adam Domonkos TarnokiMedical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary.ORCID 0000-0001-5909-3780
David Laszlo TarnokiMedical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary.ORCID 0000-0002-7001-7647
Zsofia LazarDepartment of Pulmonology, Semmelweis University, 1083 Budapest, Hungary.ORCID 0000-0003-2444-9040
Andras BikovNorth West Lung Centre, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK.ORCID 0000-0002-8983-740X
Semmelweis University · HUUniversity of Manchester · GB

Funding

Magyar Tüdőgyógyász Társaság to Andras Bikov, Martina Meszaros and David Laszlo Tarnoki
6 · The paper itself

Abstract

Intermittent hypoxia in obstructive sleep apnoea (OSA) is related to inflammation and metabolic abnormalities. Soluble low-density lipoprotein receptor-related protein-1 (sLRP-1) is involved in anti-inflammatory and metabolic processes. However, its ligand, calreticulin (CALR) promotes pro-inflammatory responses and apoptosis. Our aim was to analyse the levels of these biomarkers in OSA. We recruited 46 patients with OSA and 30 control subjects. Inpatient sleep study was performed and fasting plasma samples were collected. Triglyceride glucose index (TyG) and atherogenic index of plasma (AIP) were calculated. Plasma sLRP-1 levels were significantly lower in the OSA group compared to the controls (1.67 (0.90-2.11) mg/L vs. 1.99 (1.53-3.51) mg/L;

Indexed as

inflammationintermittent hypoxiaOSAsleep apnoea

Identifiers

PMID33916750
PMCPMC8038392
OpenAlexW3148236025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.